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  1. Autoimmune rheumatic diseases are common and confront society with serious medical, social, and financial burdens imposed by their debilitating nature. Many autoimmune diseases are associated with a particular...

    Authors: Konstantin N. Konstantinov, Antonios Tzamaloukas and Robert L. Rubin

    Citation: Autoimmunity Highlights 2013 4:52

    Content type: Review Article

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  2. Maintenance of health and physiological homeostasis is a synergistic process involving tight regulation of proteins, transcription factors and other molecular processes. The immune system consists of innate an...

    Authors: E. W. Brenu, S. L. Hardcastle, G. M. Atkinson, M. L. van Driel, S. Kreijkamp-Kaspers, K. J. Ashton, D. R. Staines and S. M. Marshall-Gradisnik

    Citation: Autoimmunity Highlights 2013 4:51

    Content type: Review

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  3. To (1) examine the occurrence and concentrations of aPS/PT and aPL in inflammatory bowel disease (IBD) patients at the beginning of and during anti-TNF-alpha therapy with infliximab; (2) investigate the link o...

    Authors: Karin Malíčková, Dana Ďuricová, Martin Bortlík, Ivana Janatková, Tomáš Zima and Milan Lukáš

    Citation: Autoimmunity Highlights 2012 4:45

    Content type: Original Article

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  4. Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) has been recently proposed by Shoenfeld and Agmon-Levin as a new entity that comprises several conditions: the macrophagic-myofasciitis syndrome...

    Authors: Esthela Loyo, Luis J. Jara, Persio David López and Ana Carolina Puig

    Citation: Autoimmunity Highlights 2012 4:44

    Content type: Case Report

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  5. Primary biliary cirrhosis (PBC) is a chronic, cholestatic, autoimmune liver disease characterised by the destruction of small- and medium-sized bile ducts. The serological hallmark of PBC includes antimitochon...

    Authors: Ilaria Bianchi, Ana Lleo, Francesca Bernuzzi, Lisa Caliari, Dan S. Smyk and Pietro Invernizzi

    Citation: Autoimmunity Highlights 2012 3:43

    Content type: Review Article

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  6. Asialoglycoprotein receptor (ASGPR) autoantibodies have been considered specific markers of autoimmune hepatitis (AIH). The exact mechanisms responsible for the development of these autoantibodies and leading ...

    Authors: Dirk Roggenbuck, Maria G. Mytilinaiou, Sergey V. Lapin, Dirk Reinhold and Karsten Conrad

    Citation: Autoimmunity Highlights 2012 3:41

    Content type: Review Article

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  7. To be able to predict who will develop autoimmune disease would allow for early treatment which may dramatically alter the course of the disease. In some cases, it may also lead to prevention of the disease de...

    Authors: Malgorzata Milkiewicz, Llorenç Caballería, Daniel S. Smyk and Piotr Milkiewicz

    Citation: Autoimmunity Highlights 2012 3:38

    Content type: Review Article

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  8. Autoimmune hepatitis (AIH) is not a disease entity restricted to man, but it can be found in other animals including canines. An increasing number of studies have focused on the immunopathogenesis of human aut...

    Authors: Christos Liaskos, Athanasios Mavropoulos, Timoklia Orfanidou, Vassiliki Spyrou, Labrini V. Athanasiou and Charalambos Billinis

    Citation: Autoimmunity Highlights 2012 3:36

    Content type: Review Article

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  9. Indirect immunofluorescence (IIF) plays an important role in immunological and immunometric assays for detecting and measuring autoantibodies. This technology was the first multiplex method used to detect card...

    Authors: Renato Tozzoli, Antonio Antico, Brunetta Porcelli and Danila Bassetti

    Citation: Autoimmunity Highlights 2012 3:35

    Content type: Review Article

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  10. The aim of our study was the characterization of anti-cytoplasmic antibodies by home-made morphological and biochemical techniques. Indeed, indirect immunofluorescence (IIF) on HEp-2 cell line is not always ex...

    Authors: Claudia Alpini, Milvia Lotzniker, Serenella Valaperta, Maria Grazia Bottone, Manuela Malatesta, Alessandro Montanelli and Giampaolo Merlini

    Citation: Autoimmunity Highlights 2012 3:33

    Content type: Original Article

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  11. The detection of antibodies is useful to diagnose and/or to classify autoimmune diseases as connective tissue diseases and vasculitis. Zenit RA is a fully automated immunoanalyzer. The aim of this study was to...

    Authors: P. Ghillani, L. Dufat, S. Himeur, M. Miyara, Z. Amoura and L. Musset

    Citation: Autoimmunity Highlights 2012 3:32

    Content type: Original Article

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  12. TSH receptor (TSHR) autoantibodies (TRAbs) play a key role in the pathogenesis of Graves’ disease. In the majority of patients, TRAbs stimulate thyroid hormone synthesis via activation of the TSHR (stimulating...

    Authors: Jadwiga Furmaniak, Jane Sanders and Bernard Rees Smith

    Citation: Autoimmunity Highlights 2012 4:28

    Content type: Review Article

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  13. Environmental and genetic factors appear to be involved in the pathogenesis of primary biliary cirrhosis (PBC), a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and...

    Authors: Daniel Smyk, Eirini I. Rigopoulou, Nicola Bizzaro and Dimitrios P. Bogdanos

    Citation: Autoimmunity Highlights 2012 4:27

    Content type: Review Article

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  14. To study in vivo effects of the human monoclonal TSH receptor (TSHR) autoantibodies M22 (stimulating type) and K1-70 (blocking type) on thyroid hormone levels in rats.

    Authors: Jadwiga Furmaniak, Jane Sanders, Stuart Young, Katarzyna Kabelis, Paul Sanders, Michele Evans, Jill Clark, Jane Wilmot and Bernard Rees Smith

    Citation: Autoimmunity Highlights 2011 3:25

    Content type: Original Article

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  15. To investigate the utility of different combinations of serum anti-carbonic anhydrase II antibodies (CA II Abs), anti-α amylase antibodies (AMY-α Abs) and IgG4 levels for the diagnosis of autoimmune pancreatit...

    Authors: M. Sánchez-Castañón, G. de las Heras-Castaño, C. Gómez and M. López-Hoyos

    Citation: Autoimmunity Highlights 2011 3:24

    Content type: Original Article

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  16. Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium size intrahepatic bile ducts. PBC patients often have concomitant aut...

    Authors: Daniel S. Smyk, Maria G. Mytilinaiou, Piotr Milkiewicz, Eirini I. Rigopoulou, Pietro Invernizzi and Dimitrios P. Bogdanos

    Citation: Autoimmunity Highlights 2011 3:23

    Content type: Review Article

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  17. MicroRNAs (miRNAs) are non-coding, single-stranded small RNAs, usually 18–25 nucleotides long, have ability to regulate gene expression post-transcriptionally. miRNAs are highly homologous, conserved and are f...

    Authors: Vivek K. Rauniyar, Wei Wu and Huan Yang

    Citation: Autoimmunity Highlights 2011 2:22

    Content type: Review Article

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  18. A serological screening assay for celiac disease (CD), designed to simultaneously detect IgA and IgG anti-tissue transglutaminase (a-tTG) and IgA and IgG deamidated gliadin peptide antibodies (a-DGP), was rece...

    Authors: Brunetta Porcelli, Fabio Ferretti, Carla Vindigni, Carlo Scapellaato and Lucia Terzuoli

    Citation: Autoimmunity Highlights 2011 2:20

    Content type: Original Article

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    The Erratum to this article has been published in Autoimmunity Highlights 2011 3:s13317-011-0026-8

  19. Antiphospholipid antibodies (aPL) are associated with the recurrent pregnancy loss and thrombosis that characterizes the antiphospholipid antibody syndrome (APS). Although the ontogeny of these pathogenic anti...

    Authors: Rohan Willis and Silvia S. Pierangeli

    Citation: Autoimmunity Highlights 2011 2:17

    Content type: Review Article

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  20. Fetomaternal alloimmune disease has traditionally been associated with haematological disease such as fetomaternal alloimmune thrombocytopaenia and Rh haemolytic anaemia, but is now known to also be organ spec...

    Authors: Daniel Smyk, Tassos Grammatikopoulos, Alexandros Daponte, Eirini I. Rigopoulou and Dimitrios P. Bogdanos

    Citation: Autoimmunity Highlights 2011 2:19

    Content type: Review Article

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  21. In recent years, the detection and characterization of (novel) autoantibodies is becoming increasingly important for the early diagnosis of autoimmune diseases. The idiopathic inflammatory myopathies (IIM, als...

    Authors: Sander H. J. van Dooren, Walther J. van Venrooij and Ger J. M. Pruijn

    Citation: Autoimmunity Highlights 2011 2:18

    Content type: Review Article

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  22. This manuscript does a review of the more frequent issues published at Autoimmunity Reviews, Journal of Autoimmunity and Autoimmunity in the period of January–December 2009. The following topics were commented...

    Authors: Jozélio Freire de Carvalho, Rosa Maria Rodrigues Pereira and Yehuda Shoenfeld

    Citation: Autoimmunity Highlights 2011 2:16

    Content type: Review Article

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  23. The aim of our study was to determine the prevalence, clinical significance of antibodies to individual histone components and to evaluate their correlation with other autoantibody specificities in a cohort of...

    Authors: Gabriella Morozzi, Francesca Bellisai, Irene Fineschi, Francesca Scaccia, Gabriella Pucci, Antonella Simpatico, Marilina Tampoia, Alessandra Chialà, Giovanni Lapadula and Mauro Galeazzi

    Citation: Autoimmunity Highlights 2011 2:15

    Content type: Original Article

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  24. Specific autoantibodies acting as TSH receptor agonists (TRAb) are responsible for Graves’ disease (GD). In the last 30 years three generations of assay methods for the detection of TRAb have become available....

    Authors: Renato Tozzoli, Graziano Kodermaz, Danilo Villalta, Marcello Bagnasco, Giampaola Pesce and Nicola Bizzaro

    Citation: Autoimmunity Highlights 2010 1:14

    Content type: Original Article

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  25. Rheumatoid arthritis (RA) is characterized by the presence of circulating rheumatoid factor (RF) and anticitrullinated peptide antibodies (ACPA), which are positive in about 70–80% of patients. APCA have a hig...

    Authors: Martina Fabris, Salvatore De Vita, Nadia Blasone, Daniela Visentini, Elena Pezzarini, Elena Pontarini, Cinzia Fabro, Luca Quartuccio, Saulle Mazzolini, Francesco Curcio and Elio Tonutti

    Citation: Autoimmunity Highlights 2010 1:13

    Content type: Original Article

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  26. The aim of this study was to estimate the diagnostic sensitivity of thyroid autoantibodies in individuals with a case-mix of subjects with thyroid disease representing that of the general population. We measur...

    Authors: Emanuele Bosi, Roberto Bianchi, Giacomo Ruotolo, Elena Bazzigaluppi, Cristina Belloni, Giliola Calori, Anna Maria Girardi, Maria Paola Garancini and Marina Scavini

    Citation: Autoimmunity Highlights 2010 1:12

    Content type: Original Article

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  27. Impairment of the clearance of apoptotic material seems to contribute to autoantigen exposure, which can initiate or maintain an autoimmune response in predisposed individuals. Complement component C1q, Creact...

    Authors: Margherita Zen, Nicola Bassi, Carla Campana, Silvano Bettio, Elena Tarricone, Linda Nalotto, Anna Ghirardello and Andrea Doria

    Citation: Autoimmunity Highlights 2010 1:10

    Content type: Review Article

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  28. The aim of this study was to assess the clinical and laboratory features of a cohort of Italian patients with adult-onset Still disease (AOSD) with particular attention on possible life-threatening complications.

    Authors: Roberta Priori, Serena Colafrancesco, Angelica Gattamelata, Manuela Di Franco, Ugo Di Tondo and Guido Valesini

    Citation: Autoimmunity Highlights 2010 1:9

    Content type: Original Article

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  29. Regulatory T cells (Treg) are a CD4+ lymphocyte subset involved in self-tolerance and autoimmunity prevention. There is evidence for a phenotypic and/or functional impairment of this cell subset during the natura...

    Authors: Alessia Alunno, Elena Bartoloni, Giuseppe Nocentini, Onelia Bistoni, Simona Ronchetti, Maria Grazia Petrillo, Carlo Riccardi and Roberto Gerli

    Citation: Autoimmunity Highlights 2010 1:8

    Content type: Review Article

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  30. Wegener’s granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome, and primary pauci-immune crescentic glomerulonephritis are associated with circulating antineutrophil cytoplasmic autoantibodies (ANC...

    Authors: Elena Csernok and Julia U. Holle

    Citation: Autoimmunity Highlights 2010 1:7

    Content type: Review Article

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  31. Microscopic enteritis (ME) is the stage of microscopic and sub-microscopic changes (microenteropathy) associated with the symptoms of gluten sensitive enteropathy leading to micronutrient deficiencies. It is c...

    Authors: Kamran Rostami, David Al Dulaimi, Mohammad Rostami Nejad, Vincenzo Villanacci and Mihai Danciu

    Citation: Autoimmunity Highlights 2010 1:6

    Content type: Review Article

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  32. Hepatitis C virus infection is associated with several extrahepatic manifestations. About 60% of patients infected with HCV develop at least one extrahepatic manifestation. The majority of these diseases seem ...

    Authors: Barbara C. Böckle and Norbert T. Sepp

    Citation: Autoimmunity Highlights 2010 1:5

    Content type: Review Article

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  33. Antiphospholipid syndrome (APS) is characterized by recurrent venous or arterial thromboses, fetal losses and thrombocytopenia in the presence of antiphospholipid antibodies, namely lupus anticoagulant, antica...

    Authors: Gerard Espinosa and Ricard Cervera

    Citation: Autoimmunity Highlights 2010 1:4

    Content type: Review Article

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  34. The antiphospholipid syndrome (APS) is characterized by a range of clinical features (primarily thrombosis and/or obstetric-related), together with the presence of antiphospholipid antibody (aPL) as detected b...

    Authors: Emmanuel J. Favaloro and Richard C. W. Wong

    Citation: Autoimmunity Highlights 2010 1:3

    Content type: Review Article

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