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Diagnostic sensitivity of thyroid autoantibodies assessed in a population-based, cross-sectional study in adults

Autoimmunity Highlights volume 1, pages 83–86 (2010)Cite this article

Abstract

The aim of this study was to estimate the diagnostic sensitivity of thyroid autoantibodies in individuals with a case-mix of subjects with thyroid disease representing that of the general population. We measured thyroid microsome (TMA), thyroid peroxidase (TPO), thyroglobulin (TGA) and thyroid-stimulating hormone (TSH) receptor (TRA) autoantibodies in subjects in the bottom (hyperthyroid end) and top (hypothyroid end) four percentiles of the TSH distribution from among participants in a population-based survey of individuals aged ≥40 years (the Cremona Study). TMA and TPO were the most sensitive autoantibodies in subjects in both the bottom percentiles (19.8% and 18.5%, respectively) and the top percentiles (51.2% and 53.8%, respectively) of the TSH distribution. TMA and TPO showed good agreement (kappa statistics 87.8%, 95% CI 80.1–95.5%) at both ends of the TSH distribution. TGA were the next most sensitive marker, although seldom detected if TMA or TPO were not present. TRA were detected only at the extremes of the TSH distribution (1st percentile, 31.8%; 100th percentile, 25.0%). We conclude that, among a case-mix of individuals with thyroid disease representing that of the general population, TMA and TPO are the most sensitive markers of thyroid disease. TGA only marginally increased the diagnostic sensitivity of TMA and TPO. TRA are sensitive markers of thyroid disease only at the extremes of thyroid function.

References

  1. Czarnocka B, Ruf J, Ferrand M et al (1985) Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases. FEBS Lett 190:147–152

    Article  PubMed  CAS  Google Scholar 

  2. Portmann L, Hamada N, Heinrich G, DeGroot LJ (1985) Antithyroid peroxidase antibody in patients with autoimmune thyroid disease: possible identity with anti-microsomal antibody. J Clin Endocrinol Metab 61:1001–1003

    Article  PubMed  CAS  Google Scholar 

  3. Sinclair D (2006) Clinical and laboratory aspects of thyroid autoantibodies. Ann Clin Biochem 43:173–183

    Article  PubMed  CAS  Google Scholar 

  4. Lind P, Langsteger W, Molnar M et al (1998) Epidemiology of thyroid diseases in iodine sufficiency. Thyroid 8:1179–1183

    Article  PubMed  CAS  Google Scholar 

  5. Laurberg P, Pedersen KM, Hreidarsson A et al (1998) Iodine intake and the pattern of thyroid disorders: a comparative epidemiological study of thyroid abnormalities in the elderly in Iceland and in Jutland, Denmark. J Clin Endocrinol Metab 83:765–769

    Article  PubMed  CAS  Google Scholar 

  6. Hollowell JG, Staehling NW, Flanders WD et al (2002) Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 87:489–499

    Article  PubMed  CAS  Google Scholar 

  7. Garancini MP, Calori G, Ruotolo G et al (1995) Prevalence of NIDDM and impaired glucose tolerance in Italy: an OGTT-based population study. Diabetologia 38:306–313

    Article  PubMed  CAS  Google Scholar 

  8. Landis JR, Koch GG (1977) An application of hierarchical kappa-type statistics in the assessment of majority agreement among multiple observers. Biometrics 33:363–374

    Article  PubMed  CAS  Google Scholar 

  9. Byrt T (1996) How good is that agreement? Epidemiology 7:561

    PubMed  CAS  Google Scholar 

  10. Vitti P, Delange F, Pinchera A et al (2003) Europe is iodine deficient. Lancet 361:1226

    Article  PubMed  Google Scholar 

  11. Vanderpump MP, Tunbridge WM, French JM et al (1995) The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol 43:55–68

    Article  CAS  Google Scholar 

  12. O’Leary PC, Feddema PH, Michelangeli VP et al (2006) Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study. Clin Endocrinol 64:97–104

    Article  Google Scholar 

  13. Bjoro T, Holmen J, Kruger O et al (2000) Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trondelag (HUNT). Eur J Endocrinol 143:639–647

    Article  PubMed  CAS  Google Scholar 

  14. Hoogendoorn EH, Hermus AR, de Vegt F et al (2006) Thyroid function and prevalence of anti-thyroperoxidase antibodies in a population with borderline sufficient iodine intake: influences of age and sex. Clin Chem 52:104–111

    Article  PubMed  CAS  Google Scholar 

  15. Bülow Pedersen I, Laurberg P, Knudsen N et al (2005) A population study of the association between thyroid autoantibodies in serum and abnormalities in thyroid function and structure. Clin Endocrinol 62:713–720

    Article  Google Scholar 

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Authors and Affiliations

  1. General Medicine, Diabetes & Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Via Olgettina, 60, 20132, Milan, Italy

    Emanuele Bosi, Roberto Bianchi & Marina Scavini

  2. Autoimmunity Unit, Laboraf, San Raffaele Scientific Institute, Milan, Italy

    Emanuele Bosi, Elena Bazzigaluppi, Cristina Belloni & Anna Maria Girardi

  3. Epidemiology Unit, Cardiovascular Department, San Raffaele Scientific Institute, Milan, Italy

    Giacomo Ruotolo & Giliola Calori

  4. Medical Direction, San Raffaele Scientific Institute, Milan, Italy

    Maria Paola Garancini

Authors
  1. Emanuele Bosi
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  2. Roberto Bianchi
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  3. Giacomo Ruotolo
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  4. Elena Bazzigaluppi
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  5. Cristina Belloni
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  6. Giliola Calori
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  7. Anna Maria Girardi
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  8. Maria Paola Garancini
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  9. Marina Scavini
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Correspondence to Emanuele Bosi.

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Bosi, E., Bianchi, R., Ruotolo, G. et al. Diagnostic sensitivity of thyroid autoantibodies assessed in a population-based, cross-sectional study in adults. Autoimmun Highlights 1, 83–86 (2010). https://doi.org/10.1007/s13317-010-0012-6

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  • DOI: https://doi.org/10.1007/s13317-010-0012-6

Keywords

Autoimmunity Highlights

ISSN: 2038-3274

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