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  1. Rheumatoid arthritis (RA) is a systemic autoimmune disease. The combination therapy of methotrexate (MTX) and Janus kinase inhibitor (JAKi) is commonly used. Patients with RA are at increased risk of malignanc...

    Authors: Vinod Solipuram, Akhila Mohan, Roshniben Patel and Ruoning Ni

    Citation: Autoimmunity Highlights 2021 12:8

    Content type: Review

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  2. Multiple Sclerosis (MS) is an autoimmune-mediated disease of the central nervous system. Experimental data suggest a role of intestinal microbiota and microbial products such as short-chain fatty acids (SCFAs)...

    Authors: Anouck Becker, Mosab Abuazab, Andreas Schwiertz, Silke Walter, Klaus C. Faßbender, Mathias Fousse and Marcus M. Unger

    Citation: Autoimmunity Highlights 2021 12:7

    Content type: Original Research

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  3. Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic beta cells. Interferon-α (IFNα), an antiviral cytokine, is expressed in the pancreatic islets in early ...

    Authors: Alexandra Coomans de Brachène, Angela Castela, Anyïshai E. Musuaya, Lorella Marselli, Piero Marchetti and Decio L. Eizirik

    Citation: Autoimmunity Highlights 2021 12:6

    Content type: Original Research

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  4. Granulomatosis with polyangiitis (GPA) is a systemic autoimmune disease characterized by small and medium vessel vasculitis. The use of biological therapies such as rituximab and infliximab has improved the tr...

    Authors: Larissa Valor-Méndez, Arnd Kleyer, Jürgen Rech, Bernhard Manger and Georg Schett

    Citation: Autoimmunity Highlights 2021 12:5

    Content type: Case Report

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  5. To evaluate the interpretation and reporting of antinuclear antibodies (ANA) by indirect immunofluorescence assay (IFA) using HEp-2 substrates based on common practice and guidance by the International Consens...

    Authors: Anne E. Tebo, Robert L. Schmidt, Kamran Kadkhoda, Lisa K. Peterson, Edward K. L. Chan, Marvin J. Fritzler and Mark H. Wener

    Citation: Autoimmunity Highlights 2021 12:4

    Content type: Original Research

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  6. Swelling and the progressive destruction of articular cartilage are major characteristics of rheumatoid arthritis (RA), a systemic autoimmune disease that directly affects the synovial joints and often causes ...

    Authors: Mohammad Javad Mousavi, Jafar Karami, Saeed Aslani, Mohammad Naghi Tahmasebi, Arash Sharafat Vaziri, Ahmadreza Jamshidi, Elham Farhadi and Mahdi Mahmoudi

    Citation: Autoimmunity Highlights 2021 12:3

    Content type: Review

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  7. Systemic lupus erythematosus (SLE) is a clinicopathologically heterogeneous chronic autoimmune disorder affecting different organs and tissues. It has been reported that there is an increasing rate of SLE inci...

    Authors: Meisam Gachpazan, Iman Akhlaghipour, Hamid Reza Rahimi, Ehsan Saburi, Majid Mojarrad, Mohammad Reza Abbaszadegan and Meysam Moghbeli

    Citation: Autoimmunity Highlights 2021 12:2

    Content type: Review

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  8. Microscopic polyangiitis (MPA) is a subtype of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), involving small and medium sized vessels, often affecting the kidneys and lungs. Anti-neutrophil...

    Authors: Arash Mollaeian, Nina Chan, Rohit Aloor, Jeffery S. Iding, Lois J. Arend, Seyed Hootan Forghani Saeidabadi and Christopher J. Haas

    Citation: Autoimmunity Highlights 2021 12:1

    Content type: Case Report

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  9. The soluble form of CTLA-4 (sCTLA-4) is associated with several autoimmune diseases. The aim of the study is to measure the serum sCTLA-4 levels in type I diabetic (T1DM) patients and to assess the presence of...

    Authors: Ahmed Al-Hakami

    Citation: Autoimmunity Highlights 2020 11:19

    Content type: Original Research

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  10. The International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP) has recently proposed nomenclature in order to harmonize ANA indirect immunofluorescence (IIF) pattern reporting. ICAP distinguishes co...

    Authors: Lieve Van Hoovels, Sylvia Broeders, Edward K. L. Chan, Luis Andrade, Wilson de Melo Cruvinel, Jan Damoiseaux, Markku Viander, Manfred Herold, Wim Coucke, Ingmar Heijnen, Dimitrios Bogdanos, Jaime Calvo-Alén, Catharina Eriksson, Ana Kozmar, Liisa Kuhi, Carolien Bonroy…

    Citation: Autoimmunity Highlights 2020 11:17

    Content type: Original Research

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  11. Marfan syndrome, G6PD deficiency, systemic lupus erythematosus (SLE), and Castleman disease are four distinctive, thoroughly investigated entities whose coincidence was never reported. However, occurrence in p...

    Authors: Sami Alhoulaiby, Lina Okar, Haya Samaan and Hisham Qalaani

    Citation: Autoimmunity Highlights 2020 11:16

    Content type: Case Report

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  12. COVID-19 epidemic has paralleled with the so called infodemic, where countless pieces of information have been disseminated on putative risk factors for COVID-19. Among those, emerged the notion that people su...

    Authors: Rossella Murtas, Anita Andreano, Federico Gervasi, Davide Guido, David Consolazio, Sara Tunesi, Laura Andreoni, Maria Teresa Greco, Maria Elena Gattoni, Monica Sandrini, Antonio Riussi and Antonio Giampiero Russo

    Citation: Autoimmunity Highlights 2020 11:15

    Content type: Original Research

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  13. Different studies have demonstrated the anti-inflammatory effects of human placental extract both in vivo and in vitro. Considering the chronic inflammatory nature of multiple sclerosis (MS) disease, we examin...

    Authors: Mir Hadi Jazayeri, Khadijeh barzaman, Reza Nedaeinia, Tayebe Aghaie and Morteza Motallebnezhad

    Citation: Autoimmunity Highlights 2020 11:14

    Content type: Original Research

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  14. For prostate cancer, signaling pathways induced by over-boarding stimulation of G-protein coupled receptors (GPCR) such as the endothelin, α1- and β-adrenergic, muscarinic and angiotensin 1 receptors were accu...

    Authors: Gerd Wallukat, Burkhard Jandrig, Niels-Peter Becker, Johann J. Wendler, Peter Göttel, Johannes Müller, Martin Schostak and Ingolf Schimke

    Citation: Autoimmunity Highlights 2020 11:13

    Content type: Original Research

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  15. Special conditions associated with laboratory autoimmune testing are not well compatible with recent developments in regulatory frameworks such as EN/ISO 15189 accreditation or in vitro diagnostic medical devi...

    Authors: Ulrich Sack, Xavier Bossuyt, Hristina Andreeva, Péter Antal-Szalmás, Nicola Bizzaro, Dimitrios Bogdanos, Elena Borzova, Karsten Conrad, Marie-Agnes Dragon-Durey, Catharina Eriksson, Katarzyna Fischer, Anna-Maija Haapala, Ingmar Heijnen, Manfred Herold, Werner Klotz, Ana Kozmar…

    Citation: Autoimmunity Highlights 2020 11:12

    Content type: Guideline

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  16. The nuclear factor-κB (NF-κB) signaling pathway regulates multiple processes in innate and adaptive immune cells. This pathway is involved in inflammation through the regulation of cytokines, chemokines, and a...

    Authors: Leila Nejatbakhsh Samimi, Elham Farhadi, Mohammad Naghi Tahmasebi, Ahmadreza Jamshidi, Arash Sharafat Vaziri and Mahdi Mahmoudi

    Citation: Autoimmunity Highlights 2020 11:11

    Content type: Review

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  17. CD59 deficiency is a congenital mutation disorder in complement pathway which can present with various manifestations.

    Authors: Vadood Javadi Parvaneh, Leila Ghasemi, Khosro Rahmani, Reza Shiari, Mahbobeh Mesdaghi, Zahra Chavoshzadeh and Seyed Hassan Tonekaboni

    Citation: Autoimmunity Highlights 2020 11:9

    Content type: Case Report

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  18. Specific anti-phospholipids antibodies (aPLs) are used as classification criteria of the antiphospholipid syndrome (APS). These aPLs, although essential for diagnosis, do not predict disease phenotypes, which ...

    Authors: Ilan Volkov, Luciana Seguro, Elaine P. Leon, László Kovács, Dirk Roggenbuck, Peter Schierack, Boris Gilburd, Andrea Doria, Maria G. Tektonidou and Nancy Agmon-Levin

    Citation: Autoimmunity Highlights 2020 11:8

    Content type: Original Research

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  19. Abnormal liver function tests are frequently seen in patients with multiple sclerosis (MS) and their origin at times is attributed to the possible co-occurrence or the de novo induction of autoimmune liver dis...

    Authors: Zisis Tsouris, Christos Liaskos, Efthymios Dardiotis, Thomas Scheper, Vana Tsimourtou, Wolfgang Meyer, George Hadjigeorgiou and Dimitrios P. Bogdanos

    Citation: Autoimmunity Highlights 2020 11:7

    Content type: Original Research

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  20. Unlike in other autoimmune liver diseases such as autoimmune hepatitis and primary biliary cholangitis, the role and nature of autoantigenic targets in primary sclerosing cholangitis (PSC), a progressive, chro...

    Authors: Steffi Lopens, Marcin Krawczyk, Maria Papp, Piotr Milkiewicz, Peter Schierack, Yudong Liu, Ewa Wunsch, Karsten Conrad and Dirk Roggenbuck

    Citation: Autoimmunity Highlights 2020 11:6

    Content type: Review

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  21. β2-Glycoprotein I (β2GPI) represents the major antigenic target for antiphospholipid antibodies (aPL), with domain 1 (D1) being identified as a risk factor for thrombosis and pregnancy complications in APS. We...

    Authors: Gayane Manukyan, Anush Martirosyan, Ludek Slavik, Sona Margaryan, Jana Ulehlova, Zuzana Mikulkova, Antonin Hlusi, Tomas Papajik and Eva Kriegova

    Citation: Autoimmunity Highlights 2020 11:5

    Content type: Original Research

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  22. The discovery and initial characterization 20 years ago of antinuclear autoantibodies (ANAs) presenting a dense fine speckled (DFS) nuclear pattern with strong staining of mitotic chromosomes, detected by indi...

    Authors: Greisha L. Ortiz-Hernandez, Evelyn S. Sanchez-Hernandez and Carlos A. Casiano

    Citation: Autoimmunity Highlights 2020 11:3

    Content type: Review

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  23. Multiple sclerosis is an immune mediated disease targeting the central nervous system. Association of non-human leukocyte antigen gene, CD58, with multiple sclerosis has been reported in several populations but i...

    Authors: Yee Ming Ching, Shanthi Viswanathan, Nurhanani Mohamed Nor, Shuwahida Shuib, Balqis Kamarudin, Salawati Mansor, Ainur Yusniza Yusof and Masita Arip

    Citation: Autoimmunity Highlights 2019 10:13

    Content type: Original Research

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  24. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed tha...

    Authors: Lucas S. Rodrigues, Luiz H. da Silva Nali, Cibele O. D. Leal, Ester C. Sabino, Eliana M. Lacerda, Caroline C. Kingdon, Luis Nacul and Camila M. Romano

    Citation: Autoimmunity Highlights 2019 10:12

    Content type: Original Research

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  25. The human monoclonal autoantibody K1-70™ binds to the TSH receptor (TSHR) with high affinity and blocks TSHR cyclic AMP stimulation by TSH and thyroid stimulating autoantibodies.

    Authors: Jadwiga Furmaniak, Jane Sanders, Jill Clark, Jane Wilmot, Paul Sanders, Yang Li and Bernard Rees Smith

    Citation: Autoimmunity Highlights 2019 10:11

    Content type: Original Research

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  26. Anti-mitochondria autoantibodies (AMA) occur in > 95% primary biliary cholangitis (PBC) patients. Biochemically normal AMA-positive (BN/AMA+) individuals, occasionally noticed by indirect immunofluorescence (I...

    Authors: Danielle Cristiane Baldo, Alessandra Dellavance, Maria Lucia Gomes Ferraz and Luis Eduardo C. Andrade

    Citation: Autoimmunity Highlights 2019 10:10

    Content type: Original Research

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  27. Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the occurrence of venous and/or arterial thrombosis, and the detection of circulating antiphospholipid antibodies. The classification c...

    Authors: Carmela Mazzoccoli, Domenico Comitangelo, Alessia D’Introno, Valeria Mastropierro, Carlo Sabbà and Antonio Perrone

    Citation: Autoimmunity Highlights 2019 10:9

    Content type: Case Report

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  28. Granulomatosis with polyangiitis (GPA) is a systemic vasculitis with a potential to involve any organ system. It remains an important cause of kidney related morbidity and mortality. Early diagnosis can be dif...

    Authors: N. Rolle, M. Muruganandam, I. Jan, F. M. Harji, J. Harrington and K. N. Konstantinov

    Citation: Autoimmunity Highlights 2019 10:8

    Content type: Case Report

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  29. Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by focal or diffuse inflammation, demyelination, axonal loss and neurodegeneration. Brain atrophy can be seen i...

    Authors: Athina Andravizou, Efthimios Dardiotis, Artemios Artemiadis, Maria Sokratous, Vasileios Siokas, Zisis Tsouris, Athina-Maria Aloizou, Ioannis Nikolaidis, Christos Bakirtzis, Georgios Tsivgoulis, Georgia Deretzi, Nikolaos Grigoriadis, Dimitrios P. Bogdanos and Georgios M. Hadjigeorgiou

    Citation: Autoimmunity Highlights 2019 10:7

    Content type: Review

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  30. Screening for paraneoplastic antibodies is often performed by means of indirect immunofluorescence on primate cerebellar slices. However, atypical immunofluorescence patterns, i.e. patterns that are not specifica...

    Authors: Joris Godelaine, Xavier Bossuyt and Koen Poesen

    Citation: Autoimmunity Highlights 2019 10:6

    Content type: Original Article

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  31. Although many assays have been developed to detect anti-aquaporin-4 (AQP4) antibodies, most of these assays require sophisticated techniques and are thus only available at specialized laboratories. The aim of ...

    Authors: Marilina Tampoia, Letizia Abbracciavento, Giuseppina Barberio, Martina Fabris and Nicola Bizzaro

    Citation: Autoimmunity Highlights 2019 10:5

    Content type: Original Article

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  32. Apart from endoscopic interventions, readily attainable cost-effective biomarkers for ulcerative colitis (UC) assessment are required. For this purpose, we evaluated differential leucocytic ratio, mainly neutr...

    Authors: Ashraf M. Okba, Mariam M. Amin, Ahmed S. Abdelmoaty, Hend E. Ebada, Amgad H. kamel, Ahmed S. Allam and Omar M. Sobhy

    Citation: Autoimmunity Highlights 2019 10:4

    Content type: Original Article

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  33. The introduction of the anti-phosphatidylserine/prothrombin (aPS/PT) antibodies among the routinely investigated anti-phospholipid (aPL) antibodies led to an improvement in anti-phospholipid syndrome (APS) lab...

    Authors: A. Cifù, R. Domenis, C. Pistis, F. Curcio and M. Fabris

    Citation: Autoimmunity Highlights 2019 10:3

    Content type: Original Article

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  34. Inflammatory bowel disease (IBD) primarily includes ulcerative colitis (UC) and Crohn’s disease (CD). Thymic stromal lymphopoietin (TSLP) is a cytokine produced by intestinal epithelial cells (IECs) with immun...

    Authors: Sahar Tahaghoghi-Hajghorbani, Abolghasem Ajami, Saeedeh Ghorbanalipoor, Zahra Hosseini-khah, Saeid Taghiloo, Peyman Khaje-Enayati and Vahid Hosseini

    Citation: Autoimmunity Highlights 2019 10:1

    Content type: Original Article

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  35. Current clinical experience with immunomodulatory agents and monoclonal antibodies in principle has established the benefit of depleting lymphocytic populations in relapsing–remitting multiple sclerosis (RRMS)...

    Authors: Georgios K. Vasileiadis, Efthymios Dardiotis, Athanasios Mavropoulos, Zisis Tsouris, Vana Tsimourtou, Dimitrios P. Bogdanos, Lazaros I. Sakkas and Georgios M. Hadjigeorgiou

    Citation: Autoimmunity Highlights 2018 9:9

    Content type: Review Article

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  36. Indirect immunofluorescence (IIF) on the human epithelial cell-line HEp-2 (or derivatives) serves as the gold standard in antinuclear antibody (ANA) screening. IIF, and its evaluation, is a labor-intensive met...

    Authors: Joyce J. B. C. van Beers, Melanie Hahn, Johanna Fraune, Kathleen Mallet, Christopher Krause, Wymke Hormann, Kai Fechner and Jan G. M. C. Damoiseaux

    Citation: Autoimmunity Highlights 2018 9:8

    Content type: Original Article

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  37. This case uniquely reports a connection between endodontically infected teeth and systemic disease, and additionally presents ozone therapy as a unique therapy and immune system modulator. It is the world’s fi...

    Authors: Robert Jay Rowen

    Citation: Autoimmunity Highlights 2018 9:7

    Content type: Review Article

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  38. Anti-phospholipid antibodies (aPL) analyzed by line immunoassay (LIA) can recognize beta2-glycoprotein I (β2GPI) domain 1 (D1) epitopes depending on β2GPI binding to distinct phospholipids. The aPL LIA was compar...

    Authors: Cecilia Nalli, Valentina Somma, Laura Andreoli, Thomas Büttner, Peter Schierack, Michael Mahler, Dirk Roggenbuck and Angela Tincani

    Citation: Autoimmunity Highlights 2018 9:6

    Content type: Original Article

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  39. Systemic lupus erythematous (SLE) is a systemic auto-immune disorder with a variety of presentations and wide spread organ involvement. We present a case report of a patient with an SLE exacerbation as well as...

    Authors: Daniel Nguyen, Farah Alsaati, Jena Deitrick, Kamel Azhar and Evelyn Sbar

    Citation: Autoimmunity Highlights 2018 9:5

    Content type: Case Report

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  40. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which has broad pleuropulmonary manifestations. One of the rare and mortal complications is acute lupus pneumonitis, which is reported very r...

    Authors: Tuğba Şişmanlar Eyüboğlu, Ayşe Tana Aslan, Yeşim Özdemir, Deniz Gezgin Yıldırım, Necla Buyan and Öznur Boyunağa

    Citation: Autoimmunity Highlights 2018 9:4

    Content type: Case Report

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  41. Thyrotropin receptor (TSHR) autoantibodies (TRAbs) are a hallmark of Graves’ disease (GD). The aim of this study was to evaluate the diagnostic accuracy of a new third generation automatic fluorescence enzyme ...

    Authors: Danilo Villalta, Federica D’Aurizio, Mirella Da Re, Debora Ricci, Francesco Latrofa and Renato Tozzoli

    Citation: Autoimmunity Highlights 2018 9:3

    Content type: Original Article

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  42. Vitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiat...

    Authors: Tohid Hassanalilou, Leila Khalili, Saeid Ghavamzadeh, Ali Shokri, Laleh Payahoo and Yaser Khaje Bishak

    Citation: Autoimmunity Highlights 2017 9:1

    Content type: Review Article

    Published on: