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Hepatitis C virus and autoimmunity

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Hepatitis C virus infection is associated with several extrahepatic manifestations. About 60% of patients infected with HCV develop at least one extrahepatic manifestation. The majority of these diseases seem to be triggered through autoimmune mechanisms, such as autoantibody production, autoreactive T cells and complex autoimmune mechanisms leading to systemic autoimmune disorders. In this review we categorize these diseases into three groups according to the main pathogenetic process involved, in particular B-cell-mediated, T-cell-mediated and complex autoimmune systemic diseases.


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Correspondence to Barbara C. Böckle.

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Böckle, B.C., Sepp, N.T. Hepatitis C virus and autoimmunity. Autoimmun Highlights 1, 23–35 (2010) doi:10.1007/s13317-010-0005-5

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  • Hepatitis C
  • Extrahepatic manifestations
  • Autoimmune mechanism
  • Mixed cryoglobulinaemia vasculitis
  • Lymphoma