The search for the Holy Grail: autoantigenic targets in primary sclerosing cholangitis associated with disease phenotype and neoplasia

Lopens, Steffi; Krawczyk, Marcin; Papp, Maria; Milkiewicz, Piotr; Schierack, Peter; Liu, Yudong; Wunsch, Ewa; Conrad, Karsten; Roggenbuck, Dirk

doi:10.1186/s13317-020-00129-x

Table 1 Clinical studies demonstrating an association of IgG and IgA to glycoprotein 2 (GP2) with fibrosis as well as disease severity in Crohn’s disease (CD), ulcerative colitis (UC) with ileal pouch anal anastomosis (IPAA) and primary sclerosing cholangitis (PSC)

From: The search for the Holy Grail: autoantigenic targets in primary sclerosing cholangitis associated with disease phenotype and neoplasia

Illness	Study design	Number of patients	Assay technique	GP2 autoantibody isotype	Associations with clinical phenotype	Reference, year
CD	Retrospective	169	ELISA	IgG	A1, B2/PD, B3(−), L2(−), L3	Bogdanos et al. 2012 [69]
				IgA	L2(−)
				IgG/IgA	A1, B2/PD, B3(−), L2(−), L3
UC with IPAA	Retrospective	26	ELISA	IgG	CD of the pouch	Werner et al. 2013 [79]
				IgA	CD of the pouch
				IgG/IgA	ND
CD	Retrospective	303	ELISA	IgG	B2, NS	Rieder et al. 2013 [152]
				IgA	B2, NS
				IgG/IgA	ND
CD	Retrospective	86	ELISA	IgG	B2/B3	Kohoutova et al. 2014 [153]
				IgA	B2/B3, B3
CD	Retrospective	323	ELISA	IgG	DD, L2(−), L3	Pavlidis et al. 2014 [68]
				IgA	A1
				IgG/IgA	A3(−), B2, B1(−), DD, L3
CD	Retrospective	224	IFA	IgG	ND	Michaelis et al. 2015 [77]
				IgA	ND
				IgG/IgA	B2, DD, L2(−)
CD	Prospective	271	ELISA	IgG	B2/B3, NS	Papp et al. 2015 [52]
				IgA	B2/B3, NS
				IgG/IgA	B2/B3, NS
			IFA	IgG	L1
				IgA	B3, L1
				IgG/IgA	–
CD	Retrospective	212	IFA	IgG	A1, B2, L2(−)	Pavlidis et al. 2016 [76]
				IgA	–
				IgG/IgA	–
CD	Retrospective	303	ELISA	IgG	NS, stenosis	Degenhardt et al. 2016 [65]
				IgA	NS, stenosis
				IgG/IgA	ND
CD	Retrospective	164	ELISA	IgG	B2/3, NS	Röber et al. 2017 [103]
				IgA	B2/3, NS, PD
				IgG/IgA	ND
PSC	Prospective	218 (138,180)	IFA	IgG	–	Jendrek et al. 2017 [87]
				IgA	Poor survival, CCA
				IgG/IgA	ND
CD	Retrospective	171	ELISA	IgG	A3(−), B3, PD	Zhang et al. 2018 [61]
				IgA	L1, L3(−), B3
				IgG/IgA	A3(−), L1, B3, PD
UC with IPAA	Prospective	177	ELISA	IgG	CD of the pouch	Cummings et al. 2018 [80]
				IgA	CD of the pouch
				IgG/IgA	ND
PSC	Retrospective	212 (23,30,83,76)	IFA	IgG	–	Sowa et al. 2018 [104]
				IgA	Cirrhosis
				IgG/IgA	–
PSC	Prospective	65	IFA	IgG	–	Tornai et al. 2018 [101]
				IgA	Predictor of shorter transplant-free survival
				IgG/IgA	–
PSC	Prospective	338	ELISA	IgG	–	Wunsch et al. 2019 (13th Dresden Symposium on Autoantibodies, September 2019)
				IgA	Predictor of shorter transplant-free survival and CCA
				IgG/IgA	–

Montreal classification of CD in accordance to age, A1: < 17 years, A2: 17–40 years, A3: > 40 years, behaviour of disease, B1: non-stricturing/non-penetrating, B2: stricturing, B3: penetrating, location of disease, L1: ileal, L2: colonic, L3: ileocolonic, L4 upper gastrointestinal tract
(−), significantly negative association; CCA, cholangiocarcinoma; DD, disease duration; ND, not determined; PD, perianal disease; NS, need for resective surgery

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ISSN: 2038-3274

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