Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity

Table 6 Toxicokinetic parameters of K1-70™ in male and female rats following IM administration of K1-70™

Day	K1-70™ dose (mg/dose)	Sex	C_max (µg/mL)	t_max (h)	AUC_(0–t) (µg h/mL)
1	2	M	101	24	13,600
1	2	F	130	24	18,300
22	2	M	274	24	43,000
22	2	F	333	72	52,400

AUC_(0–t) area under the concentration–time curve over the interval 0 to t, where t is the time of the last measurable concentration, C_max maximum serum concentration, F female, M male, t 168 h, t_max time to maximum serum concentration
The level of K1-70™ in serum was measured using the PK ELISA from RSR Ltd

ISSN: 2038-3274