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Fig. 4 | Autoimmunity Highlights

Fig. 4

From: Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity

Fig. 4

a Normal thyroid histology in a control cynomolgus monkey (×0.7 magnification). Reproduced with permission of the copyright holder, AV7 Ltd. b Cynomolgus monkey thyroid histology after K1-70™ treatment (×0.6 magnification) showing thyroid cystic follicles. There was increased severity of cystic follicles in the thyroids of male cynomolgus monkeys treated IV with K1-70™. Reproduced with permission of the copyright holder, AV7 Ltd

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