Neutrophil/lymphocyte ratio and lymphocyte/monocyte ratio in ulcerative colitis as non-invasive biomarkers of disease activity and severity

Okba, Ashraf M.; Amin, Mariam M.; Abdelmoaty, Ahmed S.; Ebada, Hend E.; kamel, Amgad H.; Allam, Ahmed S.; Sobhy, Omar M.

doi:10.1186/s13317-019-0114-8

Table 2 Laboratory parameters of the study groups (control, inactive and active ulcerative colitis)

From: Neutrophil/lymphocyte ratio and lymphocyte/monocyte ratio in ulcerative colitis as non-invasive biomarkers of disease activity and severity

	Control	Inactive	Active	Test value	p-value	Post hoc analysis
	No. = 40	No. = 40	No. = 40	Test value	p-value	P1	P2	P3
Hb (g/dL)
Mean ± SD	14.09 ± 1.01	12.79 ± 1.19	12.44 ± 1.71	17.299^a	0.000	0.000	0.000	0.232
Range	12.7–16.2	10.1–15	8.6–14.1	17.299^a	0.000	0.000	0.000	0.232
Platelet
Mean ± SD	314.90 ± 68.50	303.10 ± 68.30	304.55 ± 77.42	0.332^a	0.718	0.456	0.513	0.927
Range	187–413	194–413	178–411	0.332^a	0.718	0.456	0.513	0.927
ESR (mm/h)
Median (IQR)	10 (6–12)	18.5 (16.5–33)	28.5 (19–46)	63.411^b	0.000	0.000	0.000	0.037
Range	2–19	10–70	12–80	63.411^b	0.000	0.000	0.000	0.037
CRP (mg/dL)
Median (IQR)	0 (0–1)	2 (1–4.5)	20.5 (16–32.5)	90.859^b	0.000	0.000	0.000	0.000
Range	0–6	0–11	6–65	90.859^b	0.000	0.000	0.000	0.000
WBC
Mean ± SD	5.94 ± 1.41	6.49 ± 1.41	7.54 ± 2.06	9.820^a	0.000	0.140	0.000	0.005
Range	3.9–8.59	4.55–9.49	4.21–10.29	9.820^a	0.000	0.140	0.000	0.005
Absolute neutrophil
Mean ± SD	3.26 ± 0.87	3.62 ± 0.92	4.84 ± 1.46	22.566^a	0.000	0.147	0.000	0.000
Range	2.01–5.19	2.4–5.72	2.6–7	22.566^a	0.000	0.147	0.000	0.000
Absolute lymphocytic
Mean ± SD	2.27 ± 0.56	2.24 ± 0.53	1.87 ± 0.59	6.491^a	0.002	0.751	0.001	0.004
Range	1.5–3	1.5–3	1–3	6.491^a	0.002	0.751	0.001	0.004
Absolute monocytic
Mean ± SD	0.40 ± 0.11	0.63 ± 0.07	0.82 ± 0.15	145.993^a	0.000	0.000	0.000	0.000
Range	0.25–0.62	0.5–0.77	0.5–1	145.993^a	0.000	0.000	0.000	0.000
NLR
Mean ± SD	1.44 ± 0.19	1.64 ± 0.25	2.63 ± 0.43	179.622^a	0.000	0.004	0.000	0.000
Range	1.2–1.83	1.28–2.12	1.81–3.21	179.622^a	0.000	0.004	0.000	0.000
LMR
Mean ± SD	3.64 ± 0.49	3.58 ± 0.76	2.25 ± 0.51	69.838^a	0.000	0.625	0.000	0.000
Range	2.6–4.82	2.27–4.98	1.35–.03	69.838^a	0.000	0.625	0.000	0.000

P1: control vs inactive; P2: control vs active; P3: active vs inactive
ESR erythrocyte sedimentation rate, CRP C-reactive protein, WBC Wight blood cells; NLR neutrophil lymphocyte ratio, LMR lymphocyte monocyte ratio
^aOne Way ANOVA followed by post hoc using LSD
^bKruskall–Wallis test followed by post hoc using Mann–Whitney
^cIndependent t-test

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ISSN: 2038-3274

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