Definition of the upper reference limit for thyroglobulin antibodies according to the National Academy of Clinical Biochemistry guidelines: comparison of eleven different automated methods

Table 6 Summary of method agreement (Bland–Altman plot) for the TgAb methods

Agreement	AIA vs ARC	CEN vs ARC	CL2 vs ARC	COB vs ARC	IMM vs ARC	KRY vs ARC	LIA vs ARC	LUM vs ARC	MAG VS ARC	PHA vs ARC
No.	120	120	120	120	120	120	120	120	120	120
Bias % (±1.96 SD)	−37 (78.7 to −152.6)	133.6 (219.2 – 48)	−115.8 (−45.1 to −186.6)	155.1 (194.3–115.9)	−54.6 (106.8–216.1)	125.8 (226.7–24.8)	141.8 (189.5–94)	125 (188.3–61.7)	156.4 (201.7–111)	147.2 (190.1–104.2)

AIA AIA-2000, Tosoh Bioscience, ARC Architect, Abbott Diagnostics, CEN Advia Centaur XP, Siemens Healthineers, CI confidence intervals, CL2 AIA CL-2400, Tosoh Bioscience, COB Cobas 6000, Roche Diagnostics, e-URL experimental upper reference limit, IMM Immulite 2000 XPi, Siemens Healthineers, KRY Kryptor, Thermo Fisher Scientific BRAHMS, LIA Liaison XL, Diasorin, LUM Lumipulse G, Fujirebio, m-URL manufacturer upper reference limit, MAG Maglumi 2000 Plus, Snibe, No. number, PHA Phadia 250, Phadia AB, Thermo Fisher Scientific, r _s Spearman’s rank correlation coefficient

ISSN: 2038-3274