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Table 5 Summary of method comparison by Passing-Bablok regression and Spearman’s rank correlation for the TgAb methods

From: Definition of the upper reference limit for thyroglobulin antibodies according to the National Academy of Clinical Biochemistry guidelines: comparison of eleven different automated methods

Comparison

ARC vs AIA

ARC vs CEN

ARC vs CL2

ARC vs COB

ARC vs IMM

ARC vs KRY

ARC vs LIA

ARC vs LUM

ARC vs MAG

ARC vs PHA

No.

120

120

120

120

120

120

120

120

120

120

Slope

(95% CI)

1.15

(0.77–2.02)

26.56

(16.24–63.2)

0.34

(0.26–0.44)

5.98

(0.32 – 8.12)

1.92

(1.42–2.64)

38.36

(21.22–94.83)

5.45

(3.48–7.52)

7.03

(5.27–10.57)

17.99

(11.86–32.26)

8.33

(5.77–13.33)

y-Intercept (95% CI)

−0.75

(−1.92 to −0.26)

−29.92

(−85.36 to −14.53)

−0.15

(−0.29 to −0.03)

3.7

(0.67–6.39)

−1.9

(−2.96 to −1.17)

−47.31

(−132.72 to −22.98)

1.51

(−1.58 to 4.22)

3.51

(−8.71 to −0.77)

−13.14

(−33.37 to −4.24)

−1.63

(−9.07 to 2.15)

Equation

y = −0.75 + 1.15x

y = −29.92 + 26.56x

y = −0.15 + 0.34x

y = 3.7 + 5.98x

y = −1.9 + 1.92x

y = −47.31 + 38.36x

y = 1.51 + 5.45x

y = −3.51 + 7.03x

y = −13.14 + 17.99x

y = −1.63 + 8.33x

r s (95% CI)

0.41

(0.24–0.55)

0.17

(−0.01–0.34)

0.56

(0.42–0.67)

0.49

(0.34–0.61)

0.28

(0.1–0.43)

0.19

(0.01–0.35)

0.28

(0.11–0.44)

0.18

(−0.01–0.35)

0.23

(0.05–0.39)

0.35

(0.18–0.49)

  1. The y-intercept is expressed as IU/mL
  2. AIA, AIA-2000, Tosoh Bioscience, ARC Architect, Abbott Diagnostics, CEN Advia Centaur XP, Siemens Healthineers, CI confidence intervals, CL2 AIA CL-2400, Tosoh Bioscience, COB Cobas 6000, Roche Diagnostics, e-URL experimental upper reference limit, IMM Immulite 2000 XPi, Siemens Healthineers, KRY Kryptor, Thermo Fisher Scientific BRAHMS, LIA Liaison XL, Diasorin, LUM Lumipulse G, Fujirebio, m-URL manufacturer upper reference limit, MAG Maglumi 2000 Plus, Snibe, No. number, PHA Phadia 250, Phadia AB, Thermo Fisher Scientific, r s Spearman’s rank correlation coefficient