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Table 2 FSH receptor-activating mutations reported in the literature

From: Structure and activation of the TSH receptor transmembrane domain

Mutation

BW number

Type

Activity

References

M401T

2.43

CAM

cAMP 3.60-fold WT

[64]

T449A

3.32

CAM

cAMP 2.5-fold WT

[65]

L460R

3.43

CAM

cAMP 5-fold WT

[66]

I545T

5.46

CAM

cAMP 2.3-fold WT

[65]

I545L

5.46

CAM

cAMP 4.53-fold WT

[64]

D567N

6.30

CAM

cAMP 3-fold WT

[65]

M574I

6.37

CAM

cAMP 2.19-fold WT

[64]

A575V

6.38

CAM

cAMP 2.95-fold WT

[64]

I578L

6.41

CAM

cAMP 2.49-fold WT

[64]

T580I

6.43

CAM

cAMP 5.41-fold WT

[64]

  1. Mutations causing increase of constitutive activity less than twofold of WT are not included
  2. CAM constitutively active mutant, BW Ballesteros–Weinstein numbering, WT wild type
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