Structure and activation of the TSH receptor transmembrane domain

Autoimmunity Highlights

Table 1 Homologous GPCR experimental structures used for the comparative modelling of the TSHR, FSHR and LHR

Receptor	Species	PDB-Id	State	Resolution	TMD identity^a (%)	Used for the modelling of			References
Receptor	Species	PDB-Id	State	Resolution	TMD identity^a (%)	TMD_I	TMD_In	TMD_Ac	References
CXC chemokine receptor type 1	Human	2LNL	Inactive	NMR	20.7	✓	✖	✖	[50]
β1-Adrenergic receptor	Turkey	2VT4	Inactive	2.7 Å	18.4	✓	✖	✖	[51]
Rhodopsin	Squid	2Z73	Inactive	2.50 Å	17.6	✓	✖	✖	[52]
Adenosine A_2A receptor	Human	3EML	Inactive	2.60 Å	21.0	✓	✖	✖	[53]
CXC chemokine receptor type 4	Human	3ODU	Inactive	2.50 Å	19.5	✓	✖	✖	[54]
Histamine H1 receptor	Human	3RZE	Inactive	3.10 Å	18.0	✓	✖	✖	[55]
Sphingosine 1-phosphate receptor 1	Human	3V2Y	Inactive	2.80 Å	17.5	✓	✖	✖	[56]
Proteinase-activated receptor 1	Human	3VW7	Inactive	2.20 Å	17.6	✓	✖	✖	[57]
M3 muscarinic acetylcholine receptor	Rat	4DAJ	Inactive	3.40 Å	20.5	✓	✖	✖	[58]
κ-Opioid receptor	Human	4DJH	Inactive	2.90 Å	18.0	✓	✖	✖	[59]
μ-Opioid receptor	Mouse	4DKL	Inactive	2.80 Å	18.8	✓	✖	✖	[60]
Nociceptin/orphanin FQ receptor	Human	4EA3	Inactive	3.01 Å	20.7	✓	✖	✖	[61]
δ-Opioid receptor	Mouse	4EJ4	Inactive	3.40 Å	20.0	✓	✖	✖	[62]
Rhodopsin	Bovine	1U19	Inactive	2.20 Å	17.7	✓	✓	✖	[22]
β2-Adrenergic receptor	Human	2RH1	Inactive	2.40 Å	21.4	✓	✓	✖	[23]
M2 muscarinic acetylcholine receptor	Human	3UON	Inactive	3.00 Å	19.7	✓	✓	✖	[24]
Metarhodopsin II	Bovine	3PQR	Active	2.85 Å	17.7	✖	✖	✓	[19]
β2-Adrenergic receptor-Gs protein complex	Human	3SN6	Active	3.20 Å	21.4	✖	✖	✓	[20]
M2 muscarinic acetylcholine receptor	Human	4MQS	Active	3.50 Å	17.7	✖	✖	✓	[21]
Smoothened receptor	Human	4LKV	Inactive	2.45 Å	–	ECL-1			[63]

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