Fig. 3
From: Structure and activation of the TSH receptor transmembrane domain
Reproduced with permission from copyright holder RSR Ltd
a Distances between thyroid-stimulating hormone receptor (TSHR) Leu6657.40 and Val4211.39 and between Val4241.42 and Leu4682.58 in the inactive conformation (left panel) and active conformation (right panel) of the TSHR transmembrane domain (TMD) wild type. b Distances (dotted lines) and interactions (solid lines) between TSHR Phe6657.40 and Val4211.39 and between Val4241.42 and Leu4682.58 in the inactive conformation (left panel) and active conformation (right panel) of the TSHR TMD L665F mutant. c Distances (dotted lines) and interactions (solid lines) of TSHR Asn6747.49 with Asp460 and Asp6336.44 in the inactive conformation (left panel) and active conformation (right panel) and d between Phe5945.51 and Phe6346.54 in the inactive conformation (left panel) and active conformation (right panel) of the TSHR TMD.