Fig. 2
From: Structure and activation of the TSH receptor transmembrane domain
Reproduced with permission from copyright holder RSR Ltd
Movements of the transmembrane helices (TM) of the thyroid-stimulating hormone receptor (TSHR) transmembrane domain during the activation process. Orange arrows indicate direction of movement. a View from the extracellular side. b View from the intracellular side. c Rotation of TM6 shown by the position of Lys618 in the inactive and active states. Lys618 in the active state is marked with an asterisk.