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Table 3 Reactivity of myositis-related autoantibodies in sera from patients with sporadic inclusion body myositis (sIBM) as determined by Euroline Autoimmune Inflammatory Myopathies 16 Ag (IgG) immunoblot (Euroimmun)

From: Development and evaluation of a standardized ELISA for the determination of autoantibodies against cN-1A (Mup44, NT5C1A) in sporadic inclusion body myositis

Myositis-related autoantibodies

sIBM patients

All

(n = 75)

Anti-cN-1A-positive

(n = 28)

Correlation

to anti-cN-1A

Positive

Positive

n

Frequency

n

Frequency

r

Anti-Ro-52

11

14.7%

9

32.1%

0.381a

Anti-OJ

1

1.3%

1

3.6%

0.312c

Anti-EJ

1

1.3%

0

0.0%

 

Anti-PL-12

3

4.0%

2

7.1%

 

Anti-PL-7

3

4.0%

1

3.6%

 

Anti-SRP

3

4.0%

3

10.7%

0.315b

Anti-Jo-1

1

1.3%

0

0.0%

 

Anti-PM-Scl75

1

1.3%

0

0.0%

 

Anti-PM-Scl100

1

1.3%

1

3.6%

 

Anti-Ku

3

4.0%

2

7.1%

 

Anti-SAE1

0

0.0%

0

0.0%

 

Anti-NXP2

0

0.0%

0

0.0%

 

Anti-MDA5

0

0.0%

0

0.0%

 

Anti-TIF1Îł

2

2.7%

1

3.6%

 

Anti-Mi-2β

1

1.3%

0

0.0%

 

Anti-Mi-2α

0

0.0%

0

0.0%

 
  1. cN-1A cytosolic 5′-nucleotidase 1A, sIBM sporadic inclusion body myositis
  2. a P < 0.001, Spearman’s rank order correlation
  3. b P < 0.01, Spearman’s rank order correlation
  4. c P < 0.01, Pearson’s correlation