Fig. 2

Persistence of positive autoantibodies in the follow-up after diagnosis. a The percentage of positive ZnT8A patients remained substantially stable up to 4 years from diagnosis, then decreased significantly in patients analysed ≥5 years from diagnosis (79/133, 59.4 % within 4 years versus 27/80, 33.8 % in ≥5 years patients; *p = 0.0004, 95 %CI 1.61–5.12, OR 2.87). b Similarly, IA-2A positivity picked 1 year from diagnosis and dropped significantly ≥5 years from diagnosis). c The prevalence of positive GADA was very high 1 year from diagnosis, then slightly decreased remaining as high as at disease onset in patients analysed ≥5 years from diagnosis