Fig. 1

Alu repeat-based detection of serum cfDNA. DNA was isolated from sera of healthy individuals (CTR), RA and RRMS patients and subjected to qPCR analysis with primers for the Alu115 amplicon (a). The bars indicate the median with interquartile range. **indicates p < 0.0001; ns indicates not significant. A ROC analysis was performed to discriminate RA patients from healthy controls (b)