Table 1 Cytokines involved in Pso and PsA [80–83]
From: The Th17 axis in psoriatic disease: pathogenetic and therapeutic implications
Cytokine | Cellular source | Receptor | Targets | Role in Pso/PsA |
|---|---|---|---|---|
IL1β | Macrophages, T cells | ILR1 | Keratinocytes, FLS, ECs, OB | Inflammation, osteoclastogenesis, angiogenesis, Th17 amplification |
IL6 | Macrophages, T cells | IL6R/gp130 | DC, macrophages, T cells | Inflammation, acute phase response |
IL12 | Th1, monocytes, macrophages | IL12Rβ 1/2 |  | Th1 differentiation, inflammation, NK activation |
IL17A, IL17F | Th17, mast cells, macrophages DCs, NK cells, CD8 T cells | IL17RA/IL17RC | Keratinocytes, FB, OC | Inflammation, neutrophil recruitment, osteoclastogenesis, angiogenesis |
IL23 | T cells, mast cells, macrophages, DC | IL12Rβ/IL23R | Th17, mDC, OC | Th17 differentiation, mDC activation, osteoclastogenesis |
IL20 | Monocytes | IL20Rα/β | Th17 | Inflammation |
IL22 | Th17, NK cells, mast cells | IL22Rα/IL10Rβ | Keratinocytes, FLS | Host defence, Keratinocytes and FB proliferation, inflammation |
TNFα | Macrophages, mDC, pDC keratinocytes, FB, Th17 | TNFαR1/TNFαR2 | mDc, macrophages, keratinocytes, FLS | Proinflammatory, DC activation, immune cells recruitment, angiogenesis Keratinocyte proliferation, osteoclastogenesis, Th17 amplification |
IFNα | pDC | IFNαR | mDC | Initation of immune response |
IFNγ | Macrophages, mDC, Th1, Th17 | IFNγR | mDC, macrophages | Th1 differentiation, inflammation |
TGFβ | Macrophages, mDC | TGFβR1/TGFβR2 | Keratinocytes, FLS, T cells | Keratinocyte proliferation, inflammation, Th17 differentiation, angiogenesis |
RANKL | T cells, FB, FLS, OB | RANK | Synovial lining layer | Osteoclastogenesis |
OPG | OB, FLS | RANKL decoy R | EC below synovial lining | Osteoclastogenesis inhibition |