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Table 2 Increase of sCD30 and IgE serum levels in acute and chronic GVHD, but not in infection episodes in BMT patients

From: Skin CD30+ T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease

Type of complication

No. of samples tested

Mean (±SD) serum levels

sCD30 (U/ml)

IgE (kD/l)

Infection

 +*

49

21.0 ± 3.5

27.2 ± 4.8

 −

192

13.9 ± 2.8

23.0 ± 3.9

  

(p = 0.310)

(p = 0.184)

Grade II-IV acute GVHD

 +

42

41.1 ± 2.6

59.0 ± 4.4

 −

199

14.6 ± 2.5

24.3 ± 3.5

  

(p < 0.001)

(p < 0.001)

Chronic GVHD

 +

32

33.2 ± 2.6

53.3 ± 4.4

 −

20

13.5 ± 2.9

21.6 ± 3.9

  

(p < 0.001)

(p = 0.002)

  1. A multivariate analysis of variance (MANOVA) was used to assess the effect of each complication on post-BMT sCD30 and IgE levels corrected for simultaneous occurrence of other complications. By taking ‘patients’ as a factor, a correction for general patient levels is carried out. Since changes within patients and not between patient groups were analyzed, only data from patients who suffered from a given complication during at least one post-BMT time point measured were included in the MANOVA. P values <0.05 were accepted as significant
  2. * +/− Indicates the presence or absence of the clinical complication at the thime of sampling
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Autoimmunity Highlights

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