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Table 3 Fulfillment of ASIA criteria

From: Autoimmunity in connection with a metal implant: a case of autoimmune/autoinflammatory syndrome induced by adjuvants

Major/minor criteria Our case
Exposure to an external stimulus prior to clinical manifestations. Nickel–titanium chin implant 1 year before symptoms began.
Clinical manifestations. Myalgia, arthralgia, pyrexia, and extreme fatigue.
Typical biopsy of involved organs. ‘Reactive hyperplasia’ on two lymphadenopathy biopsies.
Removal of inciting agent induces improvement. Yes. Since January 2010 until today.
Evolvement of an autoimmune disease. Multiple clinical systemic features plus serologic evidence of inflammation.
  1. From Shoenfeld and Agmon-Levin [1]