Major criteria | Minor criteria |
---|---|
Exposure to an external stimulus (infection, vaccine, silicone, adjuvant) prior to clinical manifestations. | Appearance of autoantibodies or antibodies directed at the suspected adjuvant. |
Appearance of one of the clinical manifestations listed below: myalgia, myositis, or muscular weakness. Arthralgia and/or arthritis. Chronic fatigue, non-restful sleeps, or sleep disturbances. Neurological manifestations (especially those associated with demyelination), cognitive impairment, memory loss. Pyrexia. Dry mouth. | Other clinical manifestations (i.e., irritable bowel syndrome). |
Removal of inciting agent induces improvement. | Specific HLA (i.e., HLA DRB1, HLA DQB1) |
Typical biopsy of involved organs. | Evolvement of an autoimmune disease (i.e., multiple sclerosis, systemic sclerosis). |
There must be the presence of at least two major or one major and two minor criteria. |