Fig. 1From: Autoimmunity in connection with a metal implant: a case of autoimmune/autoinflammatory syndrome induced by adjuvantsAmplification of the immune response. Persistent exposition to nickel ions or its derivatives is capable of (1) macrophage activation and (2) antigen presentation in the context of MHC class II molecules to CD4+T cells. Repeated exposure might trigger preferential TH2-driven inflammationBack to article page