From: The X-factor in primary biliary cirrhosis: monosomy X and xenobiotics
Evidence | Reference |
---|---|
Hair dyes, nail polish, and smoking are known risk factors | |
Clusters of PBC near areas of toxic waste | [81] |
Induction of AMA in an animal model immunized with 6-bromohexanoate | [86] |
Reactivity between several xenobiotics and PBC sera | [88] |
AMA-positive PBC sera reacted against 6,8-bis(acetylthio)octanoic acid | [89] |
AMA positivity in patients with excessive acetaminophen intake; Immunoreactivity between acetaminophen metabolites and AMA | [90] |