Fig. 4

Spacefill representation of the TSHR leucine-rich domain interactive surface (based on the crystal structure of the TSHR in complex with K1-70 solved at 1.9 Å resolution). Single amino acid mutations which affect inhibition of TSH-mediated stimulation of cyclic AMP production in TSHR transfected CHO cells in the case of: a MAb 5C9 shown in red (Table 1) (antagonist and inverse agonist); b MAb-B2 shown in blue (Table 1) (antagonist); c TSHR residues that interact with MAb K1-70 (antagonist) in the TSHR–K1-70 crystal structure are shown in yellow see Table 1); d TSHR residues that interact with MAb M22 (agonist) in the TSHR–M22 crystal structure are shown in green see Table 1). Figure is reproduced from Fig. 22.4 in [29] [doi:10.1016/B978-0-12-381296-4.00022-1]. The publisher for this copyrighted material is Elsevier and a license number 2831340216726 has been granted