Fig. 4
Effects of intramuscular injection of K1-70 IgG and/or M22 IgG in rats on the serum concentration of a total T4 and b free T4 (mean ± standard deviation; n = 5). Buffer only (filled diamond); 4 μg M22/rat (filled square); 200 μg K1-70/rat (filled triangle); 200 μg K1-70/rat injected 3 h before injection of 4 μg M22/rat (times symbol); 4 μg M22/rat injected 3 h before injection of 200 μg K1-70/rat (filled circle); 200 μg K1-70 and 4 μg M22/rat injected at the same time (open circle). All three parameters were measured in the same serum sample. In the experiments when K1-70 was injected alone or in combination with M22 the total and free T4 levels were at the lower detection limits for the assays and consequently the points on the graphs are overlapping