Table 1 Myositis-specific autoantibodies and their functional activities
From: Myositis-specific autoantibodies: detection and clinical associations
Autoantibody | Autoantigen | Molecular mass (kDa) | Function of autoantigen |
|---|---|---|---|
Anti-aaRS | |||
 Anti-Jo-1/PL1 | HisRS | 54 | Aminoacylation of tRNAs |
 Anti-PL7 | ThrRS | 80 |  |
 Anti-PL12 | AlaRS | 106 |  |
 Anti-EJ | GlyRS | 75 |  |
 Anti-OJ | IleRS | 150 |  |
 Anti-KS | AsnRS | 65 |  |
 Anti-Ha | TyrRS | 58 |  |
 Anti-Zo | PheRS | 57/66 |  |
Anti-tRNA | |||
| Â | tRNAHis | Â | Translation |
| Â | tRNAAla | Â | Â |
Anti-Mi-2 | Â | Â | Â |
|  | Mi-2α | 220 | Transcription regulation + Nucleosome remodeling |
|  | Mi-2β | 218 |  |
Anti-SRP | Â | Â | Â |
| Â | SRP54 | 54 | Protein translocation to the ER |
| Â | SRP68 | 68 | Â |
| Â | SRP72 | 72 | Â |
Anti-p155/140 | Â | Â | Â |
|  | Tif1-γ | 155 | Ubiquitination |
| Â | Unknown | 140 | n.d. |
Anti-CADM-140 | Â | Â | Â |
| Â | MDA5 | 117 | Innate immunity (RNA sensor) |
Anti-SAE | Â | Â | Â |
| Â | SAE1 | 38 | Sumoylation |
| Â | SAE2 | 72 | Â |
Anti-p140 | Â | Â | Â |
|  | NXP-2 | 107 | RNA binding + nuclear transcription |