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  1. To aid in the selection of the most suitable therapeutic option in patients with diagnosis of rheumatoid arthritis according to the phase of disease, through the review of articles that identify omics biologic...

    Authors: Yolima Puentes-Osorio, Pedro Amariles, Miguel Ángel Calleja, Vicente Merino, Juan Camilo Díaz-Coronado and Daniel Taborda

    Citation: Autoimmunity Highlights 2021 12:9

    Content type: Review

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  2. Rheumatoid arthritis (RA) is a systemic autoimmune disease. The combination therapy of methotrexate (MTX) and Janus kinase inhibitor (JAKi) is commonly used. Patients with RA are at increased risk of malignanc...

    Authors: Vinod Solipuram, Akhila Mohan, Roshniben Patel and Ruoning Ni

    Citation: Autoimmunity Highlights 2021 12:8

    Content type: Review

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  3. Multiple Sclerosis (MS) is an autoimmune-mediated disease of the central nervous system. Experimental data suggest a role of intestinal microbiota and microbial products such as short-chain fatty acids (SCFAs)...

    Authors: Anouck Becker, Mosab Abuazab, Andreas Schwiertz, Silke Walter, Klaus C. Faßbender, Mathias Fousse and Marcus M. Unger

    Citation: Autoimmunity Highlights 2021 12:7

    Content type: Original Research

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  4. Type 1 diabetes (T1D) is an autoimmune disease characterized by the progressive destruction of pancreatic beta cells. Interferon-α (IFNα), an antiviral cytokine, is expressed in the pancreatic islets in early ...

    Authors: Alexandra Coomans de Brachène, Angela Castela, Anyïshai E. Musuaya, Lorella Marselli, Piero Marchetti and Decio L. Eizirik

    Citation: Autoimmunity Highlights 2021 12:6

    Content type: Original Research

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  5. Granulomatosis with polyangiitis (GPA) is a systemic autoimmune disease characterized by small and medium vessel vasculitis. The use of biological therapies such as rituximab and infliximab has improved the tr...

    Authors: Larissa Valor-Méndez, Arnd Kleyer, Jürgen Rech, Bernhard Manger and Georg Schett

    Citation: Autoimmunity Highlights 2021 12:5

    Content type: Case Report

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  6. To evaluate the interpretation and reporting of antinuclear antibodies (ANA) by indirect immunofluorescence assay (IFA) using HEp-2 substrates based on common practice and guidance by the International Consens...

    Authors: Anne E. Tebo, Robert L. Schmidt, Kamran Kadkhoda, Lisa K. Peterson, Edward K. L. Chan, Marvin J. Fritzler and Mark H. Wener

    Citation: Autoimmunity Highlights 2021 12:4

    Content type: Original Research

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  7. Swelling and the progressive destruction of articular cartilage are major characteristics of rheumatoid arthritis (RA), a systemic autoimmune disease that directly affects the synovial joints and often causes ...

    Authors: Mohammad Javad Mousavi, Jafar Karami, Saeed Aslani, Mohammad Naghi Tahmasebi, Arash Sharafat Vaziri, Ahmadreza Jamshidi, Elham Farhadi and Mahdi Mahmoudi

    Citation: Autoimmunity Highlights 2021 12:3

    Content type: Review

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  8. Systemic lupus erythematosus (SLE) is a clinicopathologically heterogeneous chronic autoimmune disorder affecting different organs and tissues. It has been reported that there is an increasing rate of SLE inci...

    Authors: Meisam Gachpazan, Iman Akhlaghipour, Hamid Reza Rahimi, Ehsan Saburi, Majid Mojarrad, Mohammad Reza Abbaszadegan and Meysam Moghbeli

    Citation: Autoimmunity Highlights 2021 12:2

    Content type: Review

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  9. Microscopic polyangiitis (MPA) is a subtype of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), involving small and medium sized vessels, often affecting the kidneys and lungs. Anti-neutrophil...

    Authors: Arash Mollaeian, Nina Chan, Rohit Aloor, Jeffery S. Iding, Lois J. Arend, Seyed Hootan Forghani Saeidabadi and Christopher J. Haas

    Citation: Autoimmunity Highlights 2021 12:1

    Content type: Case Report

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  10. The soluble form of CTLA-4 (sCTLA-4) is associated with several autoimmune diseases. The aim of the study is to measure the serum sCTLA-4 levels in type I diabetic (T1DM) patients and to assess the presence of...

    Authors: Ahmed Al-Hakami

    Citation: Autoimmunity Highlights 2020 11:19

    Content type: Original Research

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  11. The International Consensus on Antinuclear Antibody (ANA) Patterns (ICAP) has recently proposed nomenclature in order to harmonize ANA indirect immunofluorescence (IIF) pattern reporting. ICAP distinguishes co...

    Authors: Lieve Van Hoovels, Sylvia Broeders, Edward K. L. Chan, Luis Andrade, Wilson de Melo Cruvinel, Jan Damoiseaux, Markku Viander, Manfred Herold, Wim Coucke, Ingmar Heijnen, Dimitrios Bogdanos, Jaime Calvo-Alén, Catharina Eriksson, Ana Kozmar, Liisa Kuhi, Carolien Bonroy…

    Citation: Autoimmunity Highlights 2020 11:17

    Content type: Original Research

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  12. Marfan syndrome, G6PD deficiency, systemic lupus erythematosus (SLE), and Castleman disease are four distinctive, thoroughly investigated entities whose coincidence was never reported. However, occurrence in p...

    Authors: Sami Alhoulaiby, Lina Okar, Haya Samaan and Hisham Qalaani

    Citation: Autoimmunity Highlights 2020 11:16

    Content type: Case Report

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  13. COVID-19 epidemic has paralleled with the so called infodemic, where countless pieces of information have been disseminated on putative risk factors for COVID-19. Among those, emerged the notion that people su...

    Authors: Rossella Murtas, Anita Andreano, Federico Gervasi, Davide Guido, David Consolazio, Sara Tunesi, Laura Andreoni, Maria Teresa Greco, Maria Elena Gattoni, Monica Sandrini, Antonio Riussi and Antonio Giampiero Russo

    Citation: Autoimmunity Highlights 2020 11:15

    Content type: Original Research

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  14. Different studies have demonstrated the anti-inflammatory effects of human placental extract both in vivo and in vitro. Considering the chronic inflammatory nature of multiple sclerosis (MS) disease, we examin...

    Authors: Mir Hadi Jazayeri, Khadijeh barzaman, Reza Nedaeinia, Tayebe Aghaie and Morteza Motallebnezhad

    Citation: Autoimmunity Highlights 2020 11:14

    Content type: Original Research

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  15. For prostate cancer, signaling pathways induced by over-boarding stimulation of G-protein coupled receptors (GPCR) such as the endothelin, α1- and β-adrenergic, muscarinic and angiotensin 1 receptors were accu...

    Authors: Gerd Wallukat, Burkhard Jandrig, Niels-Peter Becker, Johann J. Wendler, Peter Göttel, Johannes Müller, Martin Schostak and Ingolf Schimke

    Citation: Autoimmunity Highlights 2020 11:13

    Content type: Original Research

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  16. Special conditions associated with laboratory autoimmune testing are not well compatible with recent developments in regulatory frameworks such as EN/ISO 15189 accreditation or in vitro diagnostic medical devi...

    Authors: Ulrich Sack, Xavier Bossuyt, Hristina Andreeva, Péter Antal-Szalmás, Nicola Bizzaro, Dimitrios Bogdanos, Elena Borzova, Karsten Conrad, Marie-Agnes Dragon-Durey, Catharina Eriksson, Katarzyna Fischer, Anna-Maija Haapala, Ingmar Heijnen, Manfred Herold, Werner Klotz, Ana Kozmar…

    Citation: Autoimmunity Highlights 2020 11:12

    Content type: Guideline

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  17. The nuclear factor-κB (NF-κB) signaling pathway regulates multiple processes in innate and adaptive immune cells. This pathway is involved in inflammation through the regulation of cytokines, chemokines, and a...

    Authors: Leila Nejatbakhsh Samimi, Elham Farhadi, Mohammad Naghi Tahmasebi, Ahmadreza Jamshidi, Arash Sharafat Vaziri and Mahdi Mahmoudi

    Citation: Autoimmunity Highlights 2020 11:11

    Content type: Review

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  18. CD59 deficiency is a congenital mutation disorder in complement pathway which can present with various manifestations.

    Authors: Vadood Javadi Parvaneh, Leila Ghasemi, Khosro Rahmani, Reza Shiari, Mahbobeh Mesdaghi, Zahra Chavoshzadeh and Seyed Hassan Tonekaboni

    Citation: Autoimmunity Highlights 2020 11:9

    Content type: Case Report

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  19. Specific anti-phospholipids antibodies (aPLs) are used as classification criteria of the antiphospholipid syndrome (APS). These aPLs, although essential for diagnosis, do not predict disease phenotypes, which ...

    Authors: Ilan Volkov, Luciana Seguro, Elaine P. Leon, László Kovács, Dirk Roggenbuck, Peter Schierack, Boris Gilburd, Andrea Doria, Maria G. Tektonidou and Nancy Agmon-Levin

    Citation: Autoimmunity Highlights 2020 11:8

    Content type: Original Research

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  20. Abnormal liver function tests are frequently seen in patients with multiple sclerosis (MS) and their origin at times is attributed to the possible co-occurrence or the de novo induction of autoimmune liver dis...

    Authors: Zisis Tsouris, Christos Liaskos, Efthymios Dardiotis, Thomas Scheper, Vana Tsimourtou, Wolfgang Meyer, George Hadjigeorgiou and Dimitrios P. Bogdanos

    Citation: Autoimmunity Highlights 2020 11:7

    Content type: Original Research

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  21. Unlike in other autoimmune liver diseases such as autoimmune hepatitis and primary biliary cholangitis, the role and nature of autoantigenic targets in primary sclerosing cholangitis (PSC), a progressive, chro...

    Authors: Steffi Lopens, Marcin Krawczyk, Maria Papp, Piotr Milkiewicz, Peter Schierack, Yudong Liu, Ewa Wunsch, Karsten Conrad and Dirk Roggenbuck

    Citation: Autoimmunity Highlights 2020 11:6

    Content type: Review

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  22. β2-Glycoprotein I (β2GPI) represents the major antigenic target for antiphospholipid antibodies (aPL), with domain 1 (D1) being identified as a risk factor for thrombosis and pregnancy complications in APS. We...

    Authors: Gayane Manukyan, Anush Martirosyan, Ludek Slavik, Sona Margaryan, Jana Ulehlova, Zuzana Mikulkova, Antonin Hlusi, Tomas Papajik and Eva Kriegova

    Citation: Autoimmunity Highlights 2020 11:5

    Content type: Original Research

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  23. The discovery and initial characterization 20 years ago of antinuclear autoantibodies (ANAs) presenting a dense fine speckled (DFS) nuclear pattern with strong staining of mitotic chromosomes, detected by indi...

    Authors: Greisha L. Ortiz-Hernandez, Evelyn S. Sanchez-Hernandez and Carlos A. Casiano

    Citation: Autoimmunity Highlights 2020 11:3

    Content type: Review

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  24. Multiple sclerosis is an immune mediated disease targeting the central nervous system. Association of non-human leukocyte antigen gene, CD58, with multiple sclerosis has been reported in several populations but i...

    Authors: Yee Ming Ching, Shanthi Viswanathan, Nurhanani Mohamed Nor, Shuwahida Shuib, Balqis Kamarudin, Salawati Mansor, Ainur Yusniza Yusof and Masita Arip

    Citation: Autoimmunity Highlights 2019 10:13

    Content type: Original Research

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  25. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/MS) is an incapacitating chronic disease that dramatically compromise the life quality. The CFS/ME pathogenesis is multifactorial, and it is believed tha...

    Authors: Lucas S. Rodrigues, Luiz H. da Silva Nali, Cibele O. D. Leal, Ester C. Sabino, Eliana M. Lacerda, Caroline C. Kingdon, Luis Nacul and Camila M. Romano

    Citation: Autoimmunity Highlights 2019 10:12

    Content type: Original Research

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  26. The human monoclonal autoantibody K1-70™ binds to the TSH receptor (TSHR) with high affinity and blocks TSHR cyclic AMP stimulation by TSH and thyroid stimulating autoantibodies.

    Authors: Jadwiga Furmaniak, Jane Sanders, Jill Clark, Jane Wilmot, Paul Sanders, Yang Li and Bernard Rees Smith

    Citation: Autoimmunity Highlights 2019 10:11

    Content type: Original Research

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  27. Anti-mitochondria autoantibodies (AMA) occur in > 95% primary biliary cholangitis (PBC) patients. Biochemically normal AMA-positive (BN/AMA+) individuals, occasionally noticed by indirect immunofluorescence (I...

    Authors: Danielle Cristiane Baldo, Alessandra Dellavance, Maria Lucia Gomes Ferraz and Luis Eduardo C. Andrade

    Citation: Autoimmunity Highlights 2019 10:10

    Content type: Original Research

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  28. Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the occurrence of venous and/or arterial thrombosis, and the detection of circulating antiphospholipid antibodies. The classification c...

    Authors: Carmela Mazzoccoli, Domenico Comitangelo, Alessia D’Introno, Valeria Mastropierro, Carlo Sabbà and Antonio Perrone

    Citation: Autoimmunity Highlights 2019 10:9

    Content type: Case Report

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  29. Granulomatosis with polyangiitis (GPA) is a systemic vasculitis with a potential to involve any organ system. It remains an important cause of kidney related morbidity and mortality. Early diagnosis can be dif...

    Authors: N. Rolle, M. Muruganandam, I. Jan, F. M. Harji, J. Harrington and K. N. Konstantinov

    Citation: Autoimmunity Highlights 2019 10:8

    Content type: Case Report

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  30. Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system characterized by focal or diffuse inflammation, demyelination, axonal loss and neurodegeneration. Brain atrophy can be seen i...

    Authors: Athina Andravizou, Efthimios Dardiotis, Artemios Artemiadis, Maria Sokratous, Vasileios Siokas, Zisis Tsouris, Athina-Maria Aloizou, Ioannis Nikolaidis, Christos Bakirtzis, Georgios Tsivgoulis, Georgia Deretzi, Nikolaos Grigoriadis, Dimitrios P. Bogdanos and Georgios M. Hadjigeorgiou

    Citation: Autoimmunity Highlights 2019 10:7

    Content type: Review

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  31. Screening for paraneoplastic antibodies is often performed by means of indirect immunofluorescence on primate cerebellar slices. However, atypical immunofluorescence patterns, i.e. patterns that are not specifica...

    Authors: Joris Godelaine, Xavier Bossuyt and Koen Poesen

    Citation: Autoimmunity Highlights 2019 10:6

    Content type: Original Article

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  32. Although many assays have been developed to detect anti-aquaporin-4 (AQP4) antibodies, most of these assays require sophisticated techniques and are thus only available at specialized laboratories. The aim of ...

    Authors: Marilina Tampoia, Letizia Abbracciavento, Giuseppina Barberio, Martina Fabris and Nicola Bizzaro

    Citation: Autoimmunity Highlights 2019 10:5

    Content type: Original Article

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  33. Apart from endoscopic interventions, readily attainable cost-effective biomarkers for ulcerative colitis (UC) assessment are required. For this purpose, we evaluated differential leucocytic ratio, mainly neutr...

    Authors: Ashraf M. Okba, Mariam M. Amin, Ahmed S. Abdelmoaty, Hend E. Ebada, Amgad H. kamel, Ahmed S. Allam and Omar M. Sobhy

    Citation: Autoimmunity Highlights 2019 10:4

    Content type: Original Article

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  34. The introduction of the anti-phosphatidylserine/prothrombin (aPS/PT) antibodies among the routinely investigated anti-phospholipid (aPL) antibodies led to an improvement in anti-phospholipid syndrome (APS) lab...

    Authors: A. Cifù, R. Domenis, C. Pistis, F. Curcio and M. Fabris

    Citation: Autoimmunity Highlights 2019 10:3

    Content type: Original Article

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  35. Inflammatory bowel disease (IBD) primarily includes ulcerative colitis (UC) and Crohn’s disease (CD). Thymic stromal lymphopoietin (TSLP) is a cytokine produced by intestinal epithelial cells (IECs) with immun...

    Authors: Sahar Tahaghoghi-Hajghorbani, Abolghasem Ajami, Saeedeh Ghorbanalipoor, Zahra Hosseini-khah, Saeid Taghiloo, Peyman Khaje-Enayati and Vahid Hosseini

    Citation: Autoimmunity Highlights 2019 10:1

    Content type: Original Article

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  36. Current clinical experience with immunomodulatory agents and monoclonal antibodies in principle has established the benefit of depleting lymphocytic populations in relapsing–remitting multiple sclerosis (RRMS)...

    Authors: Georgios K. Vasileiadis, Efthymios Dardiotis, Athanasios Mavropoulos, Zisis Tsouris, Vana Tsimourtou, Dimitrios P. Bogdanos, Lazaros I. Sakkas and Georgios M. Hadjigeorgiou

    Citation: Autoimmunity Highlights 2018 9:9

    Content type: Review Article

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  37. Indirect immunofluorescence (IIF) on the human epithelial cell-line HEp-2 (or derivatives) serves as the gold standard in antinuclear antibody (ANA) screening. IIF, and its evaluation, is a labor-intensive met...

    Authors: Joyce J. B. C. van Beers, Melanie Hahn, Johanna Fraune, Kathleen Mallet, Christopher Krause, Wymke Hormann, Kai Fechner and Jan G. M. C. Damoiseaux

    Citation: Autoimmunity Highlights 2018 9:8

    Content type: Original Article

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  38. This case uniquely reports a connection between endodontically infected teeth and systemic disease, and additionally presents ozone therapy as a unique therapy and immune system modulator. It is the world’s fi...

    Authors: Robert Jay Rowen

    Citation: Autoimmunity Highlights 2018 9:7

    Content type: Review Article

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  39. Anti-phospholipid antibodies (aPL) analyzed by line immunoassay (LIA) can recognize beta2-glycoprotein I (β2GPI) domain 1 (D1) epitopes depending on β2GPI binding to distinct phospholipids. The aPL LIA was compar...

    Authors: Cecilia Nalli, Valentina Somma, Laura Andreoli, Thomas Büttner, Peter Schierack, Michael Mahler, Dirk Roggenbuck and Angela Tincani

    Citation: Autoimmunity Highlights 2018 9:6

    Content type: Original Article

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  40. Systemic lupus erythematous (SLE) is a systemic auto-immune disorder with a variety of presentations and wide spread organ involvement. We present a case report of a patient with an SLE exacerbation as well as...

    Authors: Daniel Nguyen, Farah Alsaati, Jena Deitrick, Kamel Azhar and Evelyn Sbar

    Citation: Autoimmunity Highlights 2018 9:5

    Content type: Case Report

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  41. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which has broad pleuropulmonary manifestations. One of the rare and mortal complications is acute lupus pneumonitis, which is reported very r...

    Authors: Tuğba Şişmanlar Eyüboğlu, Ayşe Tana Aslan, Yeşim Özdemir, Deniz Gezgin Yıldırım, Necla Buyan and Öznur Boyunağa

    Citation: Autoimmunity Highlights 2018 9:4

    Content type: Case Report

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  42. Thyrotropin receptor (TSHR) autoantibodies (TRAbs) are a hallmark of Graves’ disease (GD). The aim of this study was to evaluate the diagnostic accuracy of a new third generation automatic fluorescence enzyme ...

    Authors: Danilo Villalta, Federica D’Aurizio, Mirella Da Re, Debora Ricci, Francesco Latrofa and Renato Tozzoli

    Citation: Autoimmunity Highlights 2018 9:3

    Content type: Original Article

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  43. Vitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiat...

    Authors: Tohid Hassanalilou, Leila Khalili, Saeid Ghavamzadeh, Ali Shokri, Laleh Payahoo and Yaser Khaje Bishak

    Citation: Autoimmunity Highlights 2017 9:1

    Content type: Review Article

    Published on: