Table 1 Genes regulated by DFS70/LEDGF

ADH and ALDH

Cellular detoxification and conversion of vitamin A to retinoic acid

[20]

ALB

Antioxidant activity through multiple-binding sites and capacity to trap radicals

[26]

AOP2/PRDX6

Peroxiredoxin involved in cellular redox regulation and protection against DNA damage by reactive oxygen species

[13]

Cell cycle genes

Cell cycle progression; knockdown of DFS70/LEDGF led to reduced levels of several cell cycle and cancer-related genes in breast cancer cells

[86]

CYGB

Reactive oxygen species scavenger activated by hypoxic and oxidative conditions

[26]

FBXO10

Ubiquitin E3 ligase associated with breast cancer susceptibility

[153]

ERp57

Disulfide isomerase involved in cellular protection against cell death induced by hydrogen peroxide

[31]

HOX genes

Transcription factors involved in development and cancer that are regulated by the complex between MLL, Menin, and DFS70/LEDGF

[75, 90, 154]

HSP27

Chaperone involved in inhibition of apoptosis and stress responses

[15, 27, 30]

IL-6

Inflammatory cytokine

[28, 29]

INV

Marker of differentiation in keratinocytes; involved in keratinization

[18]

PIP3-E/IPCEF-1

Oxygen carrier involved in peroxidase activity and translocation of cytohesins to the plasma membrane

[26]

p21

Cell cycle regulator involved in DNA damage response

[155]

SOD3

Antioxidant enzyme involved in the conversion of superoxide radicals into hydrogen peroxide and oxygen

[26]

TPO

Involved in the oxidation of iodide to iodine for the synthesis of thyroid hormone

[26]

VEGF-C

Involved in tumor lymphangiogenesis and endothelial cell growth

[24, 25]

αB-crystallin

Molecular chaperone that prevents protein aggregation under stress and contributes to lens function

[23]

γGCS-HS

Antioxidant defense enzyme upregulated by tumor necrosis factor alpha via DFS70/LEDGF

[22]