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Fig. 6 | Autoimmunity Highlights

Fig. 6

From: Twenty years of research on the DFS70/LEDGF autoantibody-autoantigen system: many lessons learned but still many questions

Fig. 6

The DFS70/LEDGF interactome. The PWWP domain is the site for several protein–protein interactions that include MeCP2, splicing factors, and others. Several proteins expressed in mammalian cells, and overexpressed in cancer cells, interact directly with the IBD, a region that also corresponds to the autoepitope targeted by anti-DFS autoantibodies. These proteins may form complexes with other proteins that come into close proximity to DFS70/LEDGF such as c-Myc and MLL1 to facilitate their tethering to transcriptionally active sites within chromatin. Some of these interactions have already been implicated in various human pathologies, including HIV/AIDS, Rett syndrome, cancer, and leukemia

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