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TableĀ 5 Accuracy of classification based on experience and participant type

From: The antinuclear antibody HEp-2 indirect immunofluorescence assay: a survey of laboratory performance, pattern recognition and interpretation

Classification nomenclature

Experience

Observations (n)

Accuracy (95% CI)

Average (95% CI)

P value

Group category (nā€‰=ā€‰276)

No

87

89 (82ā€“95)

93 (90ā€“96)

Base

Yes

189

95 (92ā€“98)

Traditional (nā€‰=ā€‰272)

No

84

80 (71ā€“89)

87 (83ā€“91)

0.014

Yes

188

90 (86ā€“94)

ICAP (nā€‰=ā€‰232)

No

67

64 (53ā€“76)

74 (68ā€“79)

0.002a

0.002b

Yes

170

77 (73ā€“84)

All (nā€‰=ā€‰785)

No

238

79 (73ā€“84)

85 (83ā€“88)

0.002**

Yes

547

88 (85ā€“91)

Group category (nā€‰=ā€‰189)

IVD

96

97 (93ā€“100)

95 (92ā€“98)

Base

CL*

93

94 (88ā€“99)

Traditional (nā€‰=ā€‰188)

IVD

96

97 (93ā€“100)

90 (86ā€“94)

0.05

CL*

92

83 (75ā€“91)

ICAP (nā€‰=ā€‰170)

IVD

95

83 (76ā€“91)

78 (71ā€“84)

0.002a

0.002b

CL*

75

71 (60ā€“81)

All (nā€‰=ā€‰547)

IVD

287

92 (89ā€“95)

88 (85ā€“91)

0.002**

CL*

260

83 (78ā€“88)

  1. HEp-2 cell IFA patterns were evaluated based on experience for all participants (yes or no), and experienced participant types (in vitro diagnostics manufacturers, IVD) and experienced clinical laboratories (CL*). Experienced CL defined as reporting all 3 main nomenclature categories. All IVD participants reported the three nomenclature categories and are rated experienced. CI: confidence interval, n number. aICAP vs Group category and bTraditional vs ICAP
  2. **Indicates significant difference between groups