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TableĀ 4 Performance of participants in the traditional and ICAP nomenclature systems

From: The antinuclear antibody HEp-2 indirect immunofluorescence assay: a survey of laboratory performance, pattern recognition and interpretation

Specimen ID

Traditional

Observations (n)

Accuracy (95% CI)

ICAP

Observations (n)

Accuracy (95% CI)

ANA-005

Centromere

24

100 (86ā€“100)

Centromere, AC-3

20

100 (83ā€“100)

ANA-002

DND

24

96 (73ā€“99)

MND, AC-6

20

85 (60ā€“95)

ANA-003

Speckled

24

100 (86ā€“100)

Nuclear CS, AC-5

18

67 (41ā€“85)

ANA-007

Speckled

24

96 (73ā€“99)

Nuclear DFS, AC-2

20

80 (55ā€“93)

ANA-010

Speckled

24

83 (62ā€“94)

Nuclear FS, AC-4

19

37 (18ā€“61)

ANA-011

Speckled/Other

24

42 (23ā€“63)

Anti-topo I, AC-29

21

62 (39ā€“81)

ANA-006

Nucleolar

24

100 (86ā€“100)

Homo nucleolar, AC-8

20

70 (46ā€“87)

ANA-004

Cytoplasmic

19

100 (86ā€“100)

AMA, AC-21

19

89 (66ā€“97)

ANA-008

Cytoplasmic

20

90 (65ā€“98)

Cytoplasmic DFS, AC-19

19

79 (53ā€“92)

ANA-009

Cytoplasmic

19

53 (30ā€“74)

Cytoplasmic FS, AC-20

19

42 (22ā€“66)

ANA-001

Mitotic

22

86 (64ā€“96)

Spindle fiber, AC-25

20

75 (50ā€“90)

ANA-012

Mitotic

24

92 (70ā€“98)

NuMA-like, AC-26

22

95 (71ā€“99)

Ā 

Overall

250

87 (82ā€“90)

Centromere, AC-3

237

74 (68ā€“79)

  1. ICAP International Consensus on Antinuclear Antibody Patterns). ID identification number, AC anti-cell, DND discrete nuclear dots, MND multiple nuclear dots, CS coarse speckled, DFS dense fine speckled, FS fine speckled, AMA anti-mitochondrial antibodies, homo homogeneous, anti-topo I anti-DNA topoisomerase I, CI confidence interval, NuMA nuclear mitotic apparatus. Variation in observation numbers in table reflects the fact that some laboratories did not report all cytoplasmic or mitotic categorical group patterns or ICAP patterns for some specimens