Transformation of fibroblast‐like synoviocytes in rheumatoid arthritis; from a friend to foe

Autoimmunity Highlights

Table 1 Epigenetic abnormalities of the RA FLS concerning cancer-like behavior

Name	Status	Function	References
PTPN11	Hypomethylated	Migration	[113]
LINE1	Hypomethylated	Aggressiveness	[114]
HDAC1 and 2	Upregulated	Apoptosis and proliferation	[117]
miR-10a	Downregulated	Migration, proliferation, invasion	[128, 129]
miR-27a	Downregulated	Invasion and migration	[130, 131]
miR-30a	Downregulated	Autophagy	[132]
miR-34a	Downregulated	Apoptosis	[133, 147]
miR-15a	Downregulated	Apoptosis	[134]
miR-124a	Downregulated	Proliferation	[132]
miR-155	Downregulated	The proliferation and invasive behavior	[136, 139]
miR-126	Upregulated	Apoptosis	[135]
miR-221	Upregulated	Invasion and migration	[140]
miR-663	Upregulated	Proliferation	[141]
miR-21	Upregulated	Proliferation	[142]

ISSN: 2038-3274