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Table 1 All of the genetic aberrations with significant effects on clinicopathological features of SLE among Iranian patients

From: Genetic and molecular biology of systemic lupus erythematosus among Iranian patients: an overview

Study (et al.)

Year

Gene

Population

Results

Tahmasebi [36]

2013

IL-1RN

213 NCa

207 SLEb

Polymorphism was correlated with SLE progression

Mahmoudi [42]

2014

IL-4

140 NC

59 SLE

Polymorphism was correlated with SLE progression

Mohammadi [47]

2019

IL-10

131 NC

116 SLE

Polymorphism was correlated with SLE progression

Mirkazemi [58]

2013

STAT4

281 NC

280 SLE

Polymorphism was correlated with SLE progression

Alesaeidi [76]

2015

MECP2

392 NC

492 SLE

Polymorphism was correlated with SLE progression

Sahebari [79]

2010

FAS

50 NC

114 SLE

Different serum levels of Fas between cases and controls

Moudi [82]

2013

FAS, FASL

149 NC

106 SLE

Polymorphism was correlated with SLE progression

Araste [86]

2010

FAS

249 NC

212 SLE

Polymorphism was correlated with SLE progression

Fathi [90]

2020

PDCD1

564 NC

253 SLE

Polymorphism was correlated with SLE progression

Mahmoudi [91]

2015

PDCD1

50 NC

202 SLE

Polymorphism was correlated with SLE progression

Rajabi [102]

2012

TNFSF4, TRAF2

57 NC

57 SLE

Increased and decreased levels of TNFSF4 and TRAF2 expressions respectively

Namazi [107]

2017

APRIL

64 NC

60 SLE

Increased serum APRIL levels

Salimi [110]

2018

ERa

186 NC

170 SLE

Polymorphism was correlated with SLE progression

Shojaa [114]

2017

CTLA‐4

304 NC

180 SLE

Polymorphism was correlated with SLE progression

Salimi [118]

2014

XRCC1

180 NC

163 SLE

Polymorphism was correlated with SLE progression

Jahantigh [122]

2015

XRCC5, XRCC7

180 NC

163 SLE

Polymorphism was correlated with SLE progression

Salimi [131]

2016

Osteopontin

180 NC

163 SLE

Polymorphism was correlated with SLE progression

Mirfeizi [135]

2012

UMCP-1

67 SLE

Increased UMCP-1 levels

Noroozinia [143]

2016

CD34

73 SLE

CD34 expression was associated with activity index

Sharifipour [147]

2013

LCN2

52 SLE

Increased urinary LCN2/creatinine level

Bahrehmand [156]

2012

MMP-2

101 NC

109 SLE

Polymorphism was correlated with SLE progression

Bahrami [175]

2020

PTPN22

93 NC

55 SLE

Polymorphism was correlated with SLE progression

Sandoughi [185]

2016

eNOS

194 NC

106 SLE

Polymorphism was correlated with SLE progression

Bahrehmand [197]

2013

PON1

83 NC

109 SLE

Polymorphism was correlated with SLE progression

Tanhapour [199]

2018

ApoE, PON1

117 NC

101 SLE

Polymorphism was correlated with SLE progression

Khoshmirsafa [203]

2019

miR-16, miR-21, and miR-155

30 NC

55 SLE

Increased expression of miR-16, miR-21, and miR-155 while miR‐141 down regulation

Vahed [206]

2018

miR-125a, miR-142-3p, miR-146a

26 NC

26 SLE

Increased circulating miR-125a and miR-146a levels while reduced level of circulating miR-142-3p

Nakhjavani [209]

2019

miR-21, miR-150, miR-423

26 NC

26 SLE

Reduced levels of circulating miR-150 while increased levels of circulating miR-21 and miR-423

Akhtari [214]

2016

KIR, HLA

273 NC

230 SLE

Polymorphism was correlated with SLE progression

Rezaieyazdi [215]

2008

HLA

83 NC

40 SLE

Polymorphism was correlated with SLE progression

  1. aNormal control (NC)
  2. bSystemic lupus erythematosus (SLE)