Table 2 Overview of (i) the frequency of reporting of the various AC patterns, (ii) the estimation whether a pattern should be classified as competent, and (iii) the clinical relevance (1 is the lowest and 5 the highest score) of the various AC patterns. The reported range represents the minimum and maximum number of responders to the specific questions posed
(i) Reporting (%) | (ii) Competent (%) | (iii) Clinical relevance score 1–2 (%) | (iii) Clinical relevance score 4–5 (%) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Laboratory | Clinicians | Laboratory | Laboratory | Clinicians | Laboratory | Clinicians | ||||||||||
Competent | Expert | Total | Competent | Expert | Total | Competent | Expert | Total | Competent | Expert | Total | |||||
n = 200–209 | n = 213–220 | n = 423–438 | n = 170–177 | n = 182–185 | n = 202–208 | n = 390–400 | n = 175–182 | n = 197–201 | n = 378–388 | n = 147–154 | n = 175–182 | n = 197–201 | n = 378–388 | n = 147–154 | ||
Nuclear | ||||||||||||||||
Homogeneous | AC-1 | 97.1 | 97.7 | 97.3 | 93.2 | 91.4 | 87.0 | 89.0 | 3.9 | 6.0 | 4.9 | 17.0 | 88.4 | 91.5 | 90.2 | 70.6 |
Speckled | AC-2,4,5 | 91.9 | 90.0 | 90.8 | 92.0 | 91.4 | 87.4 | 89.2 | 2.3 | 7.5 | 6.2 | 14.5 | 79.1 | 75.4 | 77.5 | 63.8 |
Dense fine speckled | AC-2 | 47.8 | 75.6 | 62.4 | 54.9 | 56.0 | 44.4 | 49.7 | 11.7 | 30.8 | 27.6 | 31.1 | 42.8 | 39.4 | 41.1 | 35.1 |
Fine | AC-4 | 51.5 | 73.6 | 63.3 | 60.9 | 53.8 | 54.6 | 54.8 | 6.8 | 10.6 | 12.2 | 30.2 | 55.0 | 66.7 | 61.5 | 37.6 |
Large | AC-5 | 54.1 | 73.7 | 64.7 | 40.9 | 57.8 | 56.9 | 57.8 | 7.0 | 9.1 | 11.7 | 34.5 | 56.9 | 70.2 | 64.2 | 29.7 |
Centromere | AC-3 | 99.0 | 98.2 | 98.4 | 90.3 | 89.7 | 87.3 | 88.4 | 0.8 | 4.5 | 3.1 | 7.8 | 93.4 | 93.0 | 93.3 | 83.8 |
Discrete nuclear dots | AC-6,7 | 85.4 | 84.9 | 85.2 | 72.4 | 87.0 | 80.8 | 83.8 | 4.1 | 8.0 | 8.3 | 29.1 | 65.2 | 63.8 | 64.5 | 43.7 |
multiple | AC-6 | 60.8 | 85.4 | 73.8 | 43.6 | 65.8 | 48.8 | 57.1 | 8.1 | 10.6 | 13.5 | 44.6 | 47.8 | 68.2 | 58.3 | 25.0 |
few | AC-7 | 56.4 | 80.4 | 69.3 | 35.3 | 64.5 | 47.8 | 56.0 | 10.7 | 31.3 | 26.8 | 44.6 | 32.8 | 36.9 | 35.2 | 21.6 |
Nucleolar | AC-8,9,10 | 94.7 | 94.0 | 94.2 | 83.9 | 90.8 | 86.3 | 88.4 | 3.4 | 6.0 | 6.5 | 17.4 | 77.2 | 80.4 | 79.2 | 61.1 |
Homogeneous | AC-8 | 32.8 | 52.5 | 43.3 | 51.4 | 37.5 | 32.4 | 34.9 | 10.0 | 14.6 | 17.6 | 30.5 | 44.6 | 59.6 | 52.8 | 36.4 |
Clumpy | AC-9 | 20.8 | 46.0 | 34.0 | 18.6 | 25.7 | 20.6 | 23.4 | 11.3 | 15.7 | 19.4 | 47.6 | 38.4 | 60.1 | 50.1 | 23.1 |
Punctate | AC-10 | 17.8 | 46.0 | 32.9 | 22.8 | 24.0 | 19.6 | 22.1 | 12.6 | 15.7 | 20.8 | 46.3 | 35.2 | 60.6 | 48.9 | 21.1 |
Nuclear envelope | AC-11,12 | 68.1 | 85.3 | 77.0 | 34.3 | 75.4 | 69.6 | 72.3 | 6.3 | 12.1 | 12.5 | 47.6 | 54.2 | 68.7 | 61.9 | 23.8 |
Smooth | AC-11 | 19.7 | 49.1 | 35.3 | 19.4 | 26.2 | 20.1 | 23.6 | 13.4 | 23.2 | 25.4 | 51.0 | 29.2 | 47.0 | 38.7 | 17.0 |
Punctate | AC-12 | 17.8 | 43.1 | 31.4 | 17.1 | 20.8 | 13.2 | 17.5 | 12.8 | 19.2 | 22.8 | 51.0 | 30.3 | 57.6 | 45.0 | 17.7 |
Pleiomorphic | AC-13,14 | 49.5 | 70.7 | 60.6 | 28.1 | 59.2 | 49.5 | 54.4 | 10.9 | 16.1 | 19.3 | 49.0 | 36.9 | 52.8 | 45.3 | 22.4 |
PCNA | AC-13 | 46.8 | 83.4 | 65.7 | 45.9 | 39.9 | 32.0 | 36.1 | 9.9 | 14.1 | 17.3 | 32.2 | 44.4 | 60.1 | 53.1 | 38.9 |
CENP-F | AC-14 | 28.2 | 65.0 | 47.2 | 41.5 | 24.6 | 21.2 | 23.2 | 12.6 | 28.9 | 27.6 | 33.1 | 30.3 | 37.1 | 34.1 | 40.5 |
Cytoplasmic | ||||||||||||||||
Fibrillar | AC-15,16,17 | 67.8 | 76.4 | 72.1 | 50.3 | 72.3 | 70.1 | 71.4 | 11.3 | 23.7 | 23.6 | 43.9 | 39.5 | 41.4 | 41.2 | 28.4 |
Linear | AC-15 | 48.0 | 72.6 | 61.0 | 35.1 | 50.3 | 40.7 | 45.2 | 11.5 | 15.7 | 19.7 | 47.3 | 44.1 | 56.6 | 50.9 | 22.3 |
Filamentous | AC-16 | 32.2 | 54.8 | 44.2 | 28.7 | 31.7 | 28.1 | 30.0 | 18.7 | 44.9 | 42.2 | 49.3 | 18.3 | 21.7 | 20.6 | 16.9 |
Segmental | AC-17 | 21.5 | 40.2 | 31.2 | 18.7 | 26.8 | 22.2 | 24.7 | 17.7 | 49.7 | 43.7 | 53.1 | 20.0 | 17.8 | 19.3 | 13.6 |
Speckled | AC-18,19,20 | 67.8 | 81.3 | 74.8 | 52.0 | 72.8 | 73.5 | 73.2 | 7.3 | 19.7 | 17.5 | 47.0 | 50.0 | 50.0 | 50.3 | 28.2 |
Discrete dots | AC-18 | 34.8 | 71.0 | 53.8 | 25.1 | 41.0 | 36.5 | 38.7 | 16.6 | 42.1 | 38.4 | 53.7 | 25.4 | 24.4 | 25.3 | 18.4 |
Dense fine speckled | AC-19 | 35.6 | 67.4 | 52.3 | 37.1 | 39.3 | 32.0 | 35.6 | 11.8 | 19.7 | 22.0 | 45.3 | 40.7 | 56.1 | 49.1 | 20.3 |
Fine speckled | AC-20 | 38.1 | 74.9 | 57.3 | 42.4 | 38.8 | 34.0 | 36.2 | 9.4 | 18.2 | 18.9 | 44.2 | 44.1 | 56.6 | 50.7 | 23.8 |
Reticular | AC-21 | 65.0 | 89.9 | 78.1 | 49.4 | 72.1 | 75.0 | 73.8 | 5.5 | 6.6 | 8.9 | 39.6 | 72.3 | 84.8 | 79.3 | 38.9 |
Polar / Golgi-like | AC-22 | 71.4 | 87.6 | 79.5 | 42.1 | 67.2 | 63.5 | 65.3 | 17.6 | 43.9 | 40.4 | 53.4 | 33.9 | 21.7 | 27.3 | 23.6 |
Rods and rings | AC-23 | 52.5 | 72.8 | 62.7 | 27.1 | 60.7 | 53.7 | 56.9 | 20.8 | 52.3 | 47.9 | 51.7 | 24.3 | 18.8 | 21.3 | 23.8 |
Mitotic | ||||||||||||||||
Centrosome | AC-24 | 61.1 | 78.6 | 70.3 | 43.5 | 57.1 | 48.5 | 52.8 | 18.4 | 54.3 | 46.6 | 43.9 | 23.2 | 20.3 | 21.6 | 30.4 |
Spindle fibers | AC-25 | 61.6 | 82.7 | 72.5 | 31.8 | 57.9 | 46.6 | 52.2 | 18.3 | 51.5 | 45.0 | 48.6 | 23.6 | 19.7 | 21.5 | 20.3 |
NuMA | AC-26 | 44.8 | 75.9 | 61.0 | 31.0 | 44.0 | 32.0 | 38.1 | 16.0 | 37.9 | 35.7 | 52.3 | 26.0 | 32.3 | 29.7 | 24.2 |
Intercellular bridge | AC-27 | 45.3 | 74.4 | 60.2 | 24.1 | 48.4 | 39.4 | 43.7 | 20.5 | 56.9 | 50.0 | 54.4 | 19.8 | 17.3 | 18.7 | 13.6 |
Mitotic chromosomal | AC-28 | 24.8 | 47.9 | 36.8 | 24.1 | 27.5 | 24.1 | 25.8 | 21.6 | 57.4 | 51.3 | 56.5 | 16.4 | 13.2 | 15.0 | 15.0 |