| |
(i) Reporting (%)
|
(ii) Competent (%)
|
(iii) Clinical relevance score 1–2 (%)
|
(iii) Clinical relevance score 4–5 (%)
|
|---|
|
Laboratory
|
Clinicians
|
Laboratory
|
Laboratory
|
Clinicians
|
Laboratory
|
Clinicians
|
|---|
|
Competent
|
Expert
|
Total
| |
Competent
|
Expert
|
Total
|
Competent
|
Expert
|
Total
| |
Competent
|
Expert
|
Total
| |
|---|
|
n = 200–209
|
n = 213–220
|
n = 423–438
|
n = 170–177
|
n = 182–185
|
n = 202–208
|
n = 390–400
|
n = 175–182
|
n = 197–201
|
n = 378–388
|
n = 147–154
|
n = 175–182
|
n = 197–201
|
n = 378–388
|
n = 147–154
|
|---|
|
Nuclear
|
|
Homogeneous
|
AC-1
|
97.1
|
97.7
|
97.3
|
93.2
|
91.4
|
87.0
|
89.0
|
3.9
|
6.0
|
4.9
|
17.0
|
88.4
|
91.5
|
90.2
|
70.6
|
|
Speckled
|
AC-2,4,5
|
91.9
|
90.0
|
90.8
|
92.0
|
91.4
|
87.4
|
89.2
|
2.3
|
7.5
|
6.2
|
14.5
|
79.1
|
75.4
|
77.5
|
63.8
|
|
Dense fine speckled
|
AC-2
|
47.8
|
75.6
|
62.4
|
54.9
|
56.0
|
44.4
|
49.7
|
11.7
|
30.8
|
27.6
|
31.1
|
42.8
|
39.4
|
41.1
|
35.1
|
|
Fine
|
AC-4
|
51.5
|
73.6
|
63.3
|
60.9
|
53.8
|
54.6
|
54.8
|
6.8
|
10.6
|
12.2
|
30.2
|
55.0
|
66.7
|
61.5
|
37.6
|
|
Large
|
AC-5
|
54.1
|
73.7
|
64.7
|
40.9
|
57.8
|
56.9
|
57.8
|
7.0
|
9.1
|
11.7
|
34.5
|
56.9
|
70.2
|
64.2
|
29.7
|
|
Centromere
|
AC-3
|
99.0
|
98.2
|
98.4
|
90.3
|
89.7
|
87.3
|
88.4
|
0.8
|
4.5
|
3.1
|
7.8
|
93.4
|
93.0
|
93.3
|
83.8
|
|
Discrete nuclear dots
|
AC-6,7
|
85.4
|
84.9
|
85.2
|
72.4
|
87.0
|
80.8
|
83.8
|
4.1
|
8.0
|
8.3
|
29.1
|
65.2
|
63.8
|
64.5
|
43.7
|
|
multiple
|
AC-6
|
60.8
|
85.4
|
73.8
|
43.6
|
65.8
|
48.8
|
57.1
|
8.1
|
10.6
|
13.5
|
44.6
|
47.8
|
68.2
|
58.3
|
25.0
|
|
few
|
AC-7
|
56.4
|
80.4
|
69.3
|
35.3
|
64.5
|
47.8
|
56.0
|
10.7
|
31.3
|
26.8
|
44.6
|
32.8
|
36.9
|
35.2
|
21.6
|
|
Nucleolar
|
AC-8,9,10
|
94.7
|
94.0
|
94.2
|
83.9
|
90.8
|
86.3
|
88.4
|
3.4
|
6.0
|
6.5
|
17.4
|
77.2
|
80.4
|
79.2
|
61.1
|
|
Homogeneous
|
AC-8
|
32.8
|
52.5
|
43.3
|
51.4
|
37.5
|
32.4
|
34.9
|
10.0
|
14.6
|
17.6
|
30.5
|
44.6
|
59.6
|
52.8
|
36.4
|
|
Clumpy
|
AC-9
|
20.8
|
46.0
|
34.0
|
18.6
|
25.7
|
20.6
|
23.4
|
11.3
|
15.7
|
19.4
|
47.6
|
38.4
|
60.1
|
50.1
|
23.1
|
|
Punctate
|
AC-10
|
17.8
|
46.0
|
32.9
|
22.8
|
24.0
|
19.6
|
22.1
|
12.6
|
15.7
|
20.8
|
46.3
|
35.2
|
60.6
|
48.9
|
21.1
|
|
Nuclear envelope
|
AC-11,12
|
68.1
|
85.3
|
77.0
|
34.3
|
75.4
|
69.6
|
72.3
|
6.3
|
12.1
|
12.5
|
47.6
|
54.2
|
68.7
|
61.9
|
23.8
|
|
Smooth
|
AC-11
|
19.7
|
49.1
|
35.3
|
19.4
|
26.2
|
20.1
|
23.6
|
13.4
|
23.2
|
25.4
|
51.0
|
29.2
|
47.0
|
38.7
|
17.0
|
|
Punctate
|
AC-12
|
17.8
|
43.1
|
31.4
|
17.1
|
20.8
|
13.2
|
17.5
|
12.8
|
19.2
|
22.8
|
51.0
|
30.3
|
57.6
|
45.0
|
17.7
|
|
Pleiomorphic
|
AC-13,14
|
49.5
|
70.7
|
60.6
|
28.1
|
59.2
|
49.5
|
54.4
|
10.9
|
16.1
|
19.3
|
49.0
|
36.9
|
52.8
|
45.3
|
22.4
|
|
PCNA
|
AC-13
|
46.8
|
83.4
|
65.7
|
45.9
|
39.9
|
32.0
|
36.1
|
9.9
|
14.1
|
17.3
|
32.2
|
44.4
|
60.1
|
53.1
|
38.9
|
|
CENP-F
|
AC-14
|
28.2
|
65.0
|
47.2
|
41.5
|
24.6
|
21.2
|
23.2
|
12.6
|
28.9
|
27.6
|
33.1
|
30.3
|
37.1
|
34.1
|
40.5
|
|
Cytoplasmic
|
|
Fibrillar
|
AC-15,16,17
|
67.8
|
76.4
|
72.1
|
50.3
|
72.3
|
70.1
|
71.4
|
11.3
|
23.7
|
23.6
|
43.9
|
39.5
|
41.4
|
41.2
|
28.4
|
|
Linear
|
AC-15
|
48.0
|
72.6
|
61.0
|
35.1
|
50.3
|
40.7
|
45.2
|
11.5
|
15.7
|
19.7
|
47.3
|
44.1
|
56.6
|
50.9
|
22.3
|
|
Filamentous
|
AC-16
|
32.2
|
54.8
|
44.2
|
28.7
|
31.7
|
28.1
|
30.0
|
18.7
|
44.9
|
42.2
|
49.3
|
18.3
|
21.7
|
20.6
|
16.9
|
|
Segmental
|
AC-17
|
21.5
|
40.2
|
31.2
|
18.7
|
26.8
|
22.2
|
24.7
|
17.7
|
49.7
|
43.7
|
53.1
|
20.0
|
17.8
|
19.3
|
13.6
|
|
Speckled
|
AC-18,19,20
|
67.8
|
81.3
|
74.8
|
52.0
|
72.8
|
73.5
|
73.2
|
7.3
|
19.7
|
17.5
|
47.0
|
50.0
|
50.0
|
50.3
|
28.2
|
|
Discrete dots
|
AC-18
|
34.8
|
71.0
|
53.8
|
25.1
|
41.0
|
36.5
|
38.7
|
16.6
|
42.1
|
38.4
|
53.7
|
25.4
|
24.4
|
25.3
|
18.4
|
|
Dense fine speckled
|
AC-19
|
35.6
|
67.4
|
52.3
|
37.1
|
39.3
|
32.0
|
35.6
|
11.8
|
19.7
|
22.0
|
45.3
|
40.7
|
56.1
|
49.1
|
20.3
|
|
Fine speckled
|
AC-20
|
38.1
|
74.9
|
57.3
|
42.4
|
38.8
|
34.0
|
36.2
|
9.4
|
18.2
|
18.9
|
44.2
|
44.1
|
56.6
|
50.7
|
23.8
|
|
Reticular
|
AC-21
|
65.0
|
89.9
|
78.1
|
49.4
|
72.1
|
75.0
|
73.8
|
5.5
|
6.6
|
8.9
|
39.6
|
72.3
|
84.8
|
79.3
|
38.9
|
|
Polar / Golgi-like
|
AC-22
|
71.4
|
87.6
|
79.5
|
42.1
|
67.2
|
63.5
|
65.3
|
17.6
|
43.9
|
40.4
|
53.4
|
33.9
|
21.7
|
27.3
|
23.6
|
|
Rods and rings
|
AC-23
|
52.5
|
72.8
|
62.7
|
27.1
|
60.7
|
53.7
|
56.9
|
20.8
|
52.3
|
47.9
|
51.7
|
24.3
|
18.8
|
21.3
|
23.8
|
|
Mitotic
|
|
Centrosome
|
AC-24
|
61.1
|
78.6
|
70.3
|
43.5
|
57.1
|
48.5
|
52.8
|
18.4
|
54.3
|
46.6
|
43.9
|
23.2
|
20.3
|
21.6
|
30.4
|
|
Spindle fibers
|
AC-25
|
61.6
|
82.7
|
72.5
|
31.8
|
57.9
|
46.6
|
52.2
|
18.3
|
51.5
|
45.0
|
48.6
|
23.6
|
19.7
|
21.5
|
20.3
|
|
NuMA
|
AC-26
|
44.8
|
75.9
|
61.0
|
31.0
|
44.0
|
32.0
|
38.1
|
16.0
|
37.9
|
35.7
|
52.3
|
26.0
|
32.3
|
29.7
|
24.2
|
|
Intercellular bridge
|
AC-27
|
45.3
|
74.4
|
60.2
|
24.1
|
48.4
|
39.4
|
43.7
|
20.5
|
56.9
|
50.0
|
54.4
|
19.8
|
17.3
|
18.7
|
13.6
|
|
Mitotic chromosomal
|
AC-28
|
24.8
|
47.9
|
36.8
|
24.1
|
27.5
|
24.1
|
25.8
|
21.6
|
57.4
|
51.3
|
56.5
|
16.4
|
13.2
|
15.0
|
15.0
|
- For each question, the results per pattern, are presented as percentages of the total laboratory (competent and expert reported separately) and clinician respondents. The competent patterns are highlighted in bold. The reported range represents the minimum and maximum number of responders to the specific questions posed
