Table 1 Laboratory results in the CD59-deficient patient at 30-months-old and during the observation period

CBC

Normal

Normal

Hb: 11.6 mg/dl, WBC: 4100/mm³, Absolute lymphocyte count: 890/mm³

ESR (mm/h)

2

10

23

CRP

1+

Negative

Negative

LDH (normal range < 480)

856

510

690

Uric acid (normal range)

–

3.4(2.4–5.7)

4.3(3.2–6.4)

CPK(normal range 24–229)

35

83

75

Aldolase (normal range 2–8)

15

6.7

5.6

ALT(normal range < 46)

30

20

15

AST(normal range < 31)

15

11

36

Serum electrolytes

Normal

Normal

Normal

FANA

Neg

1/20

1.8 (Neg < 1)

C3(normal range 90–180)

120

133

135

C4(normal range 10–40)

17

28.7

27

CH50(normal range 70–150)

138

125

131

Anti-ds DNA

0.9 (neg < 0.9)

1.5 (neg < 100)

Neg

Lupus anti-coagulant antibody

Neg

Neg

Neg

Anti-cardiolipin antibody (neg < 12)

2.1

1.7

Neg

Anti-B2 glycoprotein (neg < 10)

Neg

1.2

Neg

C1-inhibitor

–

0.355(Neg)

Neg

PT, PTT, INR

Normal

Normal

Normal

Lipid profile

–

–

Normal

Total protein

–

–

6.2(nl 5.7–8)

Albumin

–

–

4.3

Anti-SM antibody(IgG)

0.2(neg < 0.9)

Neg

Neg

Serum IgG

–

–

2047

Serum IgM/IgA/IgE

–

–

Normal

Urine analysis

Normal

Blood 1+

RBC: 8–10

Protein 1+

Protein (mg Urine 24 h)

–

–

2048 and 468

CSF analysis:

Protein

Normal

9

72

Glucose

Normal

57

66

WBC

Normal

0

5

RBC

Normal

0

20

A-NMO

Normal

–

–

Anti-MOG

Normal

–

–

Oligoclonal band

Normal

–

–

HLA-B5/B51

–

Neg

–

Flow cytometry: CD3, CD4, CD8, CD16, CD19, CD20, CD56

–

Normal

–