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Table 2 The main autoantibodies in receptor autoimmune diseases and their pathogenic actions

From: Receptor autoimmunity: diagnostic and therapeutic implications

Autoantibody

Acronym

Subclasses

Action

TSH receptor antibodies

TRAb

IgG

Stimulating TSH receptor

Blocking TSH receptor

Apoptosis of thyrocyte

Acetylcholine receptor antibodies

ACHRAb

IgG 1, IgG 3

Disruption of receptor signaling

Complement-dependent internalization of receptor

N-methyl-d-aspartate receptor antibodies

NMDARAb

IgG, IgA, IgM

Crosslinking and internalization of receptor

Phospholipase 2 receptor antibodies

PLAR2Ab

IgG

Thickening of capillary wall