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Table 1 The main autoantigens in receptor autoimmunity

From: Receptor autoimmunity: diagnostic and therapeutic implications

Autoantigen

Achronym

Molecular weight (kDa)

Domains

TSH receptor

TSHR

84.5

A and B subunits

Acetylcholine receptor

AChR

250.0

α, β, γ, δ, and ε subunits

N-methyl-d-aspartate receptor

NMDAR

710.0

ATD, ABD, TMD, CTD

Phospholipase 2 receptor

PLAR2

180.0

ECD, TMD, CTD

  1. ECD extracellular domain, ABD agonist binding domain, TMD transmembrane domain, CTD intracellular domain