Associations between HLA and autoimmune neurological diseases with autoantibodies

Autoimmunity Highlights

Table 2 Main HLA associations with neurological diseases with autoantibodies of IgG1 isotype

Autoantibody	HLA	Population	References
Anti-Hu	DQB102-DRB103	SCLC-PNS	[23]
Anti-Yo	DQA101:03-DQB106:03-DRB1*13:01	Ovarian cancer	[29]
Anti-VGCC	B*08:01	Non-paraneoplastic LEMS (69%)	[37]
Anti-AchR	B*08:01	EOMG	[40, 46, 48]
	DQB105-DRB116	LOMG	[52, 53]
	DRB1*15	LOMG	[40, 54]
	DQA103-DQB103-DRB1*09	EOMG	[55]
	DQA103-DQB106-DRB1*13	EOMG	[55]
	DRB1*04:04	Pre-pubertal EOMG	[41]
Anti-NMDAR	DRB1*16:02		[96]
Anti-NMDAR	B*07:02	Adult onset	[95]
Anti-GAD	DQB102-DRB103	SPS & CA	[100,101,102]
Anti-AQP4	DRB1*03	Caucasian and mixed	[106, 109, 110, 114]
	DPB1*05:01	East Asia	[117, 118]
	DRB1*16:02	East Asia	[117, 118]

AchR acetylcholine receptor, AQP4 aquaporin 4, CA cerebellar ataxia, EOMG early-onset myasthenia gravis, GAD glutamic acid decarboxylase, HLA human leukocyte antigen, JOMG juvenile-onset myasthenia gravis, LEMS Lambert-Eaton myasthenic syndrome, LOMG late-onset myasthenia gravis, NMDAR N-methyl-d-aspartate receptor, PNS paraneoplastic neurological syndrome, SCLC small-cell lung cancer, SPS stiff-person syndrome, VGCC voltage-gated calcium channels

ISSN: 2038-3274