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Table 2 Main HLA associations with neurological diseases with autoantibodies of IgG1 isotype

From: Associations between HLA and autoimmune neurological diseases with autoantibodies

Autoantibody HLA Population References
Anti-Hu DQB1*02-DRB1*03 SCLC-PNS [23]
Anti-Yo DQA1*01:03-DQB1*06:03-DRB1*13:01 Ovarian cancer [29]
Anti-VGCC B*08:01 Non-paraneoplastic LEMS (69%) [37]
Anti-AchR B*08:01 EOMG [40, 46, 48]
DQB1*05-DRB1*16 LOMG [52, 53]
DRB1*15 LOMG [40, 54]
DQA1*03-DQB1*03-DRB1*09 EOMG [55]
DQA1*03-DQB1*06-DRB1*13 EOMG [55]
DRB1*04:04 Pre-pubertal EOMG [41]
Anti-NMDAR DRB1*16:02   [96]
B*07:02 Adult onset [95]
Anti-GAD DQB1*02-DRB1*03 SPS & CA [100,101,102]
Anti-AQP4 DRB1*03 Caucasian and mixed [106, 109, 110, 114]
DPB1*05:01 East Asia [117, 118]
DRB1*16:02 East Asia [117, 118]
  1. AchR acetylcholine receptor, AQP4 aquaporin 4, CA cerebellar ataxia, EOMG early-onset myasthenia gravis, GAD glutamic acid decarboxylase, HLA human leukocyte antigen, JOMG juvenile-onset myasthenia gravis, LEMS Lambert-Eaton myasthenic syndrome, LOMG late-onset myasthenia gravis, NMDAR N-methyl-d-aspartate receptor, PNS paraneoplastic neurological syndrome, SCLC small-cell lung cancer, SPS stiff-person syndrome, VGCC voltage-gated calcium channels