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Fig. 1 | Autoimmunity Highlights

Fig. 1

From: Associations between HLA and autoimmune neurological diseases with autoantibodies

Fig. 1

HLA-complex on chromosome 6, showing the main class I and II HLA genes (top). Structure of class I (bottom left) and class II (bottom right) HLA molecules. The alpha chain of class I molecule has three domains (α1–3) and includes the peptide-binding groove. The β2-microglobulin (β2) is not encoded by HLA genes. The class II molecules are made up of one alpha and one beta chain that each contains two domains (α1, α2, β1, β2); both form the peptide-binding groove

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