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Table 9 Toxicokinetic parameters of K1-70™ in male and female monkeys following IV administration of different doses of K1-70™

From: Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity

Day

K1-70™ dose (mg/kg/dose)

Sex

Cmax (µg/mL)

tmax (h)

AUC(0–t) (µg h/mL)

1

10

M

275

0.6

27,000

F

348

0.6

28,900

30

M

1090

0.6

97,500

F

1000

0.6

93,800

100

M

2820

0.6

254,000

F

3180

0.6

268,000

22

10

M

688

0.6

64,100

F

597

8.5

66,900

30

M

1910

0.6

195,000

F

1710

8.5

173,000

100

M

5610

0.6

595,000

F

5560

0.6

592,000

  1. The level of K1-70™ in serum was measured using the PK ELISA from RSR Ltd
  2. AUC(0–t) area under the concentration–time curve over the interval 0 to t, where t is the time of the last measurable concentration, Cmax maximum serum concentration, F female, M male, t 168 h, tmax time to maximum serum concentration