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Table 8 Thyroid hormone levels in male and female monkeys post IM administration of different doses of K1-70™

From: Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity

Day

K1-70™ dose (mg/dose)

Sex

TSH (µlU/mL)

T3 (nmol/L)

T4 (nmol/L)

Mean ± SD

Mean ± SD

Mean ± SD

Predose

5

M

0.58 ± 0.20

2.45 ± 0.37

53.8 ± 12.2

F

0.95 ± 0.56

2.75 ± 0.36

62.7 ± 11.8

Day 7

5

M

20.08 ± 9.30

0.96 ± 0.20

27.4 ± 8.6

F

23.03 ± 10.44

0.84 ± 0.28

22.5 ± 3.3

Day 22

5

M

78.69 ± 35.66

1.18 ± 0.45

28.2 ± 13.2

F

103.97 ± 26.90

1.21 ± 0.61

24.4 ± 4.9

  1. Mean is of n = 5 animals per group per sex
  2. Levels of thyroid hormones in serum, TSH, Total T3 and Total T4 were measured using Siemens Centaur immunoassay system
  3. M male, F female, T3 triiodothyronine, T4 thyroxine, TSH thyroid stimulating hormone
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