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Table 5 Toxicokinetic parameters of K1-70™ in male and female rats following IV administration of different doses of K1-70™

From: Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity

Day

K1-70™ dose (mg/kg/dose)

Sex

Cmax (µg/mL)

tmax (h)

AUC(0–t) (µg h/mL)

1

15

M

273

0.6

20,800

F

389

0.6

24,000

50

M

1360

0.6

84,800

F

1510

0.6

86,200

150

M

4360

0.6

255,000

F

4470

0.6

229,000

22

15

M

840

0.6

82,400

F

846

0.6

83,100

50

M

2630

0.6

255,000

F

2610

0.6

267,000

150

M

11,200

0.6

804,000

F

6540

0.6

701,000

  1. AUC(0–t) area under the concentration–time curve over the interval 0 to t, where t is the time of the last measurable concentration, Cmax maximum serum concentration, F female, M male, t 168 h, tmax time to maximum serum concentration
  2. The level of K1-70™ in serum was measured using the PK ELISA from RSR Ltd