Table 2 Groups of cynomolgus monkeys of the Macaca fascicularis strain for IV and IM administration of different doses of K1-70™
Group | Dose route | Dose level (mg/kg/dose) | Number of animals | |||
|---|---|---|---|---|---|---|
Subgroup 1 | ||||||
Toxicity | Treatment free | |||||
Male | Female | Male | Female | |||
1 | IV | 0 (control) | 3 | 3 | 2 | 2 |
2 | IV | 10 (low) | 3 | 3 | – | – |
3 | IV | 30 (intermediate) | 3 | 3 | – | – |
4 | IV | 100 (high) | 3 | 3 | 2 | 2 |
5 | IM | 5 mg per dose (low) | 3 | 3 | 2 | 2 |