Fig. 5From: Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activitya Normal pituitary histology showing the pars distalis in a control cynomolgus monkey (×20 magnification). Reproduced with permission of the copyright holder, AV7 Ltd. b Cynomolgus monkey pituitary histology after K1-70™ treatment showing vacuolation in the pars distalis (×20 magnification). Pituitary vacuolation in the pars distalis was recorded in most animals treated with all doses of K1-70™. Reproduced with permission of the copyright holder, AV7 LtdBack to article page