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Fig. 5 | Autoimmunity Highlights

Fig. 5

From: Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity

Fig. 5

a Normal pituitary histology showing the pars distalis in a control cynomolgus monkey (×20 magnification). Reproduced with permission of the copyright holder, AV7 Ltd. b Cynomolgus monkey pituitary histology after K1-70™ treatment showing vacuolation in the pars distalis (×20 magnification). Pituitary vacuolation in the pars distalis was recorded in most animals treated with all doses of K1-70™. Reproduced with permission of the copyright holder, AV7 Ltd

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