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Table 2 Descriptive analysis of biochemical and autoantibody parameters in successive time stations in BN/AMA+ individuals and PBC patients

From: Evolving liver inflammation in biochemically normal individuals with anti-mitochondria antibodies

 

Parameters

ALP (U/L)a

ɣGT (U/L)a

ELF scorea

Anti-PDC-E2 (AU)a

Avidity anti-PDC-E2 (%)a

IIF-AMA (titer)b

BN/AMA+ individuals

 T0

69.2 (27–158)

35.3 (3–265)

7.9 (6–9.9)

2.0 (0.1–6.0)

61 (16–118)

320 (40–20,480)

 T1

71.3 (28–105)

45.2 (8–191)

8.4 (6.4–10.5)

1.9 (0.3–6.4)

54 (Ø–105)

640 (Ø–10,240)

 T2

63.4 (30–127)

33.2 (6–148)

8.8 (7.3–10.5)

2.4 (0.2–5.9)

55 (Ø–101)

160 (Ø–10,240)

 T3

62.2 (31–131)

31.2 (4–179)

8.8 (7.2–10.7)

2.4 (0.2–5.9)

70 (33–99)

640 (Ø–20,480)

 T4

63.0 (38–79)

25.2 (7–99)

9.2 (7.4–10.8)

2.9 (0.2–7.0)

62 (Ø–101)

480 (Ø–10,240)

 T5

72.0 (42–198)

31.9 (10–111)

8.7 (5.8–10.2)

2.4 (0.2–7.4)

63 (Ø–97)

320 (Ø–10,240)

 T6

79.0 (42–126)

39.8 (7–82)

9.3 (8.5–11.2)

3.9 (0.2–7.7)

88 (5–121)

640 (160–20480)

 T7

52.8 (37–67)

82.2 (12–308)

9.2 (9–9.5)

2.5 (0.3–4.9)

64 (Ø–93)

160 (Ø–2560)

PBC patients

 T0

200.4 (52–776)

226.8 (10–1221)

8.6 (5.8–13.5)

2.9 (0.2–7.2)

68 (26–105)

1280 (40–20,480)

 T1

138.5 (77–360)

145.6 (15–524)

9.1 (7–10.6)

3.4 (0.4–7.4)

71 (Ø–97)

1280 (Ø–5120)

 T2

86.7 (35–128)

95.6 (19–341)

9.1 (6.9–11.4)

3.4 (0.4–6.7)

69 (Ø–96)

480 (Ø–5120)

 T3

138.7 (46–490)

105.7 (10–307)

9 (4.7–12.5)

3.6 (0.4–7.8)

77 (Ø–112)

1280 (80–20,480)

 T4

130.6 (55–259)

144.1 (13–473)

9.7 (7.8–13.4)

3.4 (0.3–6.4)

77 (Ø–104)

1280 (Ø–10,240)

 T5

311.6 (66–518)

387.8 (10–1545)

10.6 (9.1–12.1)

5.1 (1.7–7.4)

81 (3–105)

1280 (40–10,240)

 T6

167.3 (65–359)

138.6 (13–579)

9.7 (8.4–12)

4.3 (0.3–6.7)

90 (59–107)

1280 (320–10,240)

 T7

190.0 (110–527)

258.4 (21–1448)

11.2 (10–12.1)

5.5 (2.6–7.2)

91 (68–108)

1280 (320–10,240)

  1. Ø no reactivity, BN/AMA+ biochemically normal individuals with positive AMA test, PBC primary biliary cholangitis, ALP alkaline phosphatase, ɣGT gamma glutamyltransfarase, ELF score enhanced liver fibrosis score, PDC-E2 pyruvate dehydrogenase complex E2 subunit, IIF-AMA indirect immunofluorescence assays for anti-mitochondria antibodies
  2. aMean and range
  3. bMedian and range