Skip to main content

Table 3 Receiver-operating characteristics curve analysis of anti-phospholipid antibodies (aPL) detected by enzyme-linked immunosorbent assay (ELISA) and line immunoassay (LIA) in 34 patients with anti-phospholipid syndrome and 41 disease controls

From: Anti-phospholipid IgG antibodies detected by line immunoassay differentiate patients with anti-phospholipid syndrome and other autoimmune diseases

aPL AUC SE 95% CI
ELISA
 aD1/aD4–5 0.760 0.0597 0.647–0.851
 aβ2GPI IgG 0.705 0.0617 0.588–0.805
 aβ2GPI IgM 0.534*,$,§ 0.0679 0.416–0.651
 aCL IgG 0.725 0.0598 0.609–0.821
 aCL IgM 0.559*,$,§ 0.0679 0.440–0.674
LIA
 aβ2GPI IgG 0.691 0.0638 0.574–0.793
 aCL IgG 0.660 0.0651 0.541–0.765
 aPS IgG 0.716& 0.0613 0.600–0.814
 aPG IgG 0.723& 0.0630 0.608–0.821
 aPT IgG 0.701 0.0628 0.584–0.801
  1. Area under the curve (AUC) was determined for the ratio of anti-domain 1 of beta2 glycoprotein I (aD1) and domains 4–5 (D4–5) antibody reactivity (D4–5) by ELISA and compared with those for criteria aPL determined by ELISA and aPL IgG by LIA
  2. aβ2GPI anti-beta2 glycoprotein I, aCL anti-cardiolipin, aPG anti-phosphatidyl-glycerol, aPI anti-phosphatidylinositol, aPS anti-phosphatidyl-serine, aPT anti-prothrombin, CI confidence interval, SE standard error
  3. AUC comparison of ELISA
  4. *p < 0.05 for the comparison to the AUC of the ratio of aD1 to D4–5
  5. $p < 0.05 for the comparison to the AUC of aβ2GPI IgG
  6. §p < 0.05 for the comparison to the AUC of aCL IgG
  7. AUC comparison of LIA
  8. &p < 0.05 for the comparison to the AUC of aCL IgG
Back to article page

Autoimmunity Highlights

ISSN: 2038-3274

Contact us