| |
Primary thrombotic or obstetric APS (n = 34)
|
SARD (n = 41)
|
Healthy subjects (n = 20)
|
|---|
|
Sex, no. (%) female
|
31/34 (91%)
|
36/41 (88%)
|
9/20 (55%)
|
|
Autoimmune disease
|
34/34 (100%)
|
41/41 (100%)
|
0 (0%)
|
|
Primary APS
|
34/34 (100%)
|
0 (0%)
|
0 (0%)
|
|
SLE
|
0 (0%)
|
11/41 (27%)
|
0 (0%)
|
|
SSj
|
0 (0%)
|
2/41 (5%)
|
0 (0%)
|
|
SLE + SSj
|
0 (0%)
|
3/41 (7%)
|
0 (0%)
|
|
DLE
|
0 (0%)
|
1/41 (2%)
|
0 (0%)
|
|
PBC
|
0 (0%)
|
3/41 (7%)
|
0 (0%)
|
|
SSc
|
0 (0%)
|
2/41 (5%)
|
0 (0%)
|
|
DM/PM
|
0 (0%)
|
4/41 (10%)
|
0 (0%)
|
|
UCTD
|
0 (0%)
|
15/41 (37%)
|
0 (0%)
|
|
Thrombosis
|
19/34 (56%)
|
0 (0%)
|
0 (0%)
|
|
Arterial
|
7/19 (37%)
|
0 (0%)
|
0 (0%)
|
|
Venous
|
12/19 (63%)
|
0 (0%)
|
0 (0%)
|
|
Obstetric manifestations
|
20/34 (59%)
|
0 (0%)
|
NA
|
|
Pregnancy loss
|
15/20 (75%)
|
0 (0%)
|
NA
|
|
Preeclampsia
|
5/20 (25%)
|
0 (0%)
|
NA
|
|
Laboratory features
| | | |
|
LAC positivity
|
24/34 (71%)
|
18/41 (44%)
|
NP
|
|
aβ2GPI IgG, median OD (25–75th percentile)
|
1.470 (0.929–1.747)
|
1.004 (0.655–1.298)
|
0.139 (0.047–0.444)
|
|
aβ2GPI IgM, median OD (25–75th percentile)
|
0.350 (0.165–0.576)
|
0.450 (0.202–0.838)
|
0.088 (0.049–0.132)
|
- APS anti-phospholipid syndrome, aCL anti-cardiolipin antibodies, DLE discoid lupus erythematosus, DM/PM dermato/polymyositis, LAC lupus anti-coagulant, NA not applicable, NP not performed, OD optical density, PBC primary biliary cirrhosis, SARD systemic autoimmune rheumatic disease, SLE systemic lupus erythematosus, SSc systemic scleroderma, SjS Sjögren syndrome, UCTD undifferentiated connective tissue disease
