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Table 3 ANA-reflex test procedure with patterns related to markers found in autoimmune liver diseases

From: The ANA-reflex test as a model for improving clinical appropriateness in autoimmune diagnostics

ANA-IIF pattern on HEp-2 cells Reflex test(s)
Cytoplasmic reticular/AMA ≥1:160 Anti-mitochondrial M2 or E3 or MIT3
Multiple nuclear dots ≥1:160 Anti-Sp100
Nuclear envelope Anti-gp210
Cytoplasmic linear-actin ≥1:160 IIF on kidney, stomach, and liver, to confirm anti-actin antibodies