Table 3 IL17 family members [102–104]
From: The Th17 axis in psoriatic disease: pathogenetic and therapeutic implications
Member | Alternative names | Receptor | Main functions |
|---|---|---|---|
IL17A | CTLA-8 | IL17RA, IL17RC | Neutrophils recruitment, host defence, autoimmunity |
IL17B | CX1, NERF | IL17RB | Proinflammatory activity? |
IL17C | CX2 | IL17RE | Proinflammatory activity? |
IL17D | IL27, IL27A | Unknown | Proinflammatory activity? |
IL17E | IL25 | IL17RB, IL17RA | Stimulates Th2 response, suppresses Th17 response |
IL17F | ML-1 | IL17RA, IL17RC | Neutrophil recruitment, host defence, autoimmunity |