The Th17 axis in psoriatic disease: pathogenetic and therapeutic implications

Autoimmunity Highlights

Table 2 Susceptibility genes involved in Pso and PsA from GWA studies

Gene	Name	Chromosome	Pathway	Other diseases	References
IL23A	IL23 p19	12q13	IL23		[42]
IL12B	IL12/IL23 p40	5q33	IL23	IBD, PsA, AS, MS	[42, 53, 84–86]
IL23R	IL23R	1p31	IL23	IBD, PsA, AS	[42, 53, 87, 88]
TYK2	Tyrosine kinase 2	19p13	IL23	IBD, SLE, MS?	[89–92]
TRAF3IP2	TNF receptor-associated factor 3 interacting protein 2	6q21	NFKB, IL17	PsA, RA, CD	[92–96]
TNFA IP3	TNFα-induced protein3	6q23	NFKB	PsA, SLE, RA, CD	[42, 95, 97, 98]
TNIP1	TNFAIP3-interacting protein 1	5q33	NFKB	PsA, SLE, SSc	[42, 99, 100]
DEFB4	Defensin β 4	16q12	IL17		[101]

IBD inflammatory bowel disease, PsA psoriatic arthritis, AS ankylosing spondylitis, MS multiple sclerosis, CD celiac disease, RA rheumatoid arthritis, SLE systemic lupus erythematous, SSc systemic sclerosis

ISSN: 2038-3274