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Table 2 Susceptibility genes involved in Pso and PsA from GWA studies

From: The Th17 axis in psoriatic disease: pathogenetic and therapeutic implications

Gene Name Chromosome Pathway Other diseases References
IL23A IL23 p19 12q13 IL23   [42]
IL12B IL12/IL23 p40 5q33 IL23 IBD, PsA, AS, MS [42, 53, 84–86]
IL23R IL23R 1p31 IL23 IBD, PsA, AS [42, 53, 87, 88]
TYK2 Tyrosine kinase 2 19p13 IL23 IBD, SLE, MS? [89–92]
TRAF3IP2 TNF receptor-associated factor 3 interacting protein 2 6q21 NFKB, IL17 PsA, RA, CD [92–96]
TNFA IP3 TNFα-induced protein3 6q23 NFKB PsA, SLE, RA, CD [42, 95, 97, 98]
TNIP1 TNFAIP3-interacting protein 1 5q33 NFKB PsA, SLE, SSc [42, 99, 100]
DEFB4 Defensin β 4 16q12 IL17   [101]
  1. IBD inflammatory bowel disease, PsA psoriatic arthritis, AS ankylosing spondylitis, MS multiple sclerosis, CD celiac disease, RA rheumatoid arthritis, SLE systemic lupus erythematous, SSc systemic sclerosis
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